Linked Life Data

20639110

Source:http://linkedlifedata.com/resource/pubmed/id/20639110

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
2010-7-19
pubmed:abstractText
A series of novel benzimidazole derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in the HepG2.2.15 cell line. The preliminary SAR was discussed. Compound 12a, with IC50<0.41 microM and SI>81.2, was the most promising compound and selected as the benchmark compound for further optimization.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1464-3391
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5048-55
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Design and synthesis of novel benzimidazole derivatives as inhibitors of hepatitis B virus.
pubmed:affiliation
Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't