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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2010-7-19
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pubmed:abstractText |
The novel islet-specific protein PANcreatic DERived Factor (PANDER; FAM3B) has been extensively characterized with respect to the beta-cell, and these studies suggest a potential function for PANDER in the regulation of glucose homeostasis. Little is known regarding PANDER in pancreatic -cells, which are critically involved in maintaining euglycemia. Here we present the first report elucidating the expression and regulation of PANDER within the alpha-cell. Pander mRNA and protein are detected in alpha-cells, with primary localization to a glucagon-negative granular cytosolic compartment. PANDER secretion from alpha-cells is nutritionally and hormonally regulated by l-arginine and insulin, demonstrating similarities and differences with glucagon. Signaling via the insulin receptor (IR) through the PI3K and Akt/PKB node is required for insulin-stimulated PANDER release. The separate localization of PANDER and glucagon is consistent with their differential regulation, and the effect of insulin suggests a paracrine/endocrine effect on PANDER release. This provides further insight into the potential glucose-regulatory role of PANDER.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20638985-10426370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20638985-10600680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20638985-12160727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20638985-12414805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20638985-12941769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20638985-12985958,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20638985-1382779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20638985-15541576,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20638985-16027126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20638985-16102856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20638985-16249448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20638985-16399504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20638985-16493415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20638985-17259375,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20638985-17962352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20638985-18522835,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20638985-2862019,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20638985-9593714
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1872-8057
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
30
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pubmed:volume |
325
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
36-45
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20638985-Animals,
pubmed-meshheading:20638985-Arginine,
pubmed-meshheading:20638985-Cell Culture Techniques,
pubmed-meshheading:20638985-Cells, Cultured,
pubmed-meshheading:20638985-Cytokines,
pubmed-meshheading:20638985-Dose-Response Relationship, Drug,
pubmed-meshheading:20638985-Gene Expression,
pubmed-meshheading:20638985-Glucagon-Secreting Cells,
pubmed-meshheading:20638985-Glucose,
pubmed-meshheading:20638985-In Situ Hybridization, Fluorescence,
pubmed-meshheading:20638985-Insulin,
pubmed-meshheading:20638985-Male,
pubmed-meshheading:20638985-Mice,
pubmed-meshheading:20638985-Mice, Inbred C57BL,
pubmed-meshheading:20638985-Paracrine Communication,
pubmed-meshheading:20638985-Tissue Distribution
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pubmed:year |
2010
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pubmed:articleTitle |
Characterization of the expression, localization, and secretion of PANDER in alpha-cells.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104-4318, USA. carnegie@email.chop.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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