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pubmed-article:20638279pubmed:abstractTextA high-throughput screening campaign identified 4-((E)-styryl)-pyrimidin-2-ylamine (11) as a positive allosteric modulator of the metabotropic glutamate (mGlu) receptor subtype 4. An evaluation of the structure-activity relationships (SAR) of 11 is described and the efficacy of this compound in a haloperidol-induced catalepsy rat model following oral administration is presented.lld:pubmed
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pubmed-article:20638279pubmed:copyrightInfo2010 Elsevier Ltd. All rights reserved.lld:pubmed
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pubmed-article:20638279pubmed:articleTitleAn orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction.lld:pubmed
pubmed-article:20638279pubmed:affiliationEvotec (UK) Ltd, 114 Milton Park, Abingdon, OX14 4SD, UK. stephen.east@evotec.comlld:pubmed
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