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rdf:type |
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lifeskim:mentions |
umls-concept:C0205531,
umls-concept:C0226896,
umls-concept:C0234131,
umls-concept:C0442027,
umls-concept:C0597357,
umls-concept:C0599779,
umls-concept:C0935763,
umls-concept:C1415308,
umls-concept:C1446409,
umls-concept:C1527415,
umls-concept:C1709060
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pubmed:issue |
16
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|
pubmed:dateCreated |
2010-7-27
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|
pubmed:abstractText |
A high-throughput screening campaign identified 4-((E)-styryl)-pyrimidin-2-ylamine (11) as a positive allosteric modulator of the metabotropic glutamate (mGlu) receptor subtype 4. An evaluation of the structure-activity relationships (SAR) of 11 is described and the efficacy of this compound in a haloperidol-induced catalepsy rat model following oral administration is presented.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Aug
|
|
pubmed:issn |
1464-3405
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|
pubmed:author |
pubmed-author:BamfordSamanthaS,
pubmed-author:DietzMatthias G AMG,
pubmed-author:EastStephen PSP,
pubmed-author:EickmeierChristianC,
pubmed-author:FergerBorisB,
pubmed-author:FleggAdamA,
pubmed-author:GemkowMark JMJ,
pubmed-author:GerlachKaiK,
pubmed-author:HeilkerRalfR,
pubmed-author:HengererBastianB,
pubmed-author:KoteyAdrianA,
pubmed-author:LokePuiP,
pubmed-author:SchänzleGerhardG,
pubmed-author:SchubertHans-DieterHD,
pubmed-author:ScottJohnJ,
pubmed-author:WhittakerMarkM,
pubmed-author:WilliamsMildredM,
pubmed-author:ZawadzkiPrzemyslawP
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pubmed:copyrightInfo |
2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
|
|
pubmed:volume |
20
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
4901-5
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pubmed:meshHeading |
pubmed-meshheading:20638279-Administration, Oral,
pubmed-meshheading:20638279-Allosteric Regulation,
pubmed-meshheading:20638279-Animals,
pubmed-meshheading:20638279-Catalepsy,
pubmed-meshheading:20638279-High-Throughput Screening Assays,
pubmed-meshheading:20638279-Humans,
pubmed-meshheading:20638279-Models, Animal,
pubmed-meshheading:20638279-Motor Activity,
pubmed-meshheading:20638279-Pyrimidines,
pubmed-meshheading:20638279-Rats,
pubmed-meshheading:20638279-Rats, Sprague-Dawley,
pubmed-meshheading:20638279-Receptors, Metabotropic Glutamate,
pubmed-meshheading:20638279-Structure-Activity Relationship,
pubmed-meshheading:20638279-Styrenes
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pubmed:year |
2010
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|
pubmed:articleTitle |
An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction.
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pubmed:affiliation |
Evotec (UK) Ltd, 114 Milton Park, Abingdon, OX14 4SD, UK. stephen.east@evotec.com
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pubmed:publicationType |
Journal Article
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