Linked Life Data

20638258

Source:http://linkedlifedata.com/resource/pubmed/id/20638258

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2011-1-10
pubmed:abstractText
The objectives of this work were to carry out a comparative chemical study and to evaluate the antinociceptive and anti-inflammatory activities of ethanol extracts (EtOHE) and vanilic acid (VA) from cultivated and wild Amburana cearensis A.C. Smith (Fabaceae), an endangered species used in Northeast Brazil for the treatment of asthma. The HPLC analysis of EtOHE, showed that coumarin (CM) and VA were the major constituents from the cultivated plant, while in the extract from the wild plant the major constituents were amburoside A (AMB) and CM. Pharmacological tests were performed with male Swiss mice or male Wistar rats acutely administered with 100-400mg/kg, p.o. of EtOHEs or 12.5-50mg/kg, p.o. of VA. EtOHEs from A. cearensis with 4, 7 or 9 months of cultivation significantly inhibited, from 32 to 64%, both phases of the formalin test in mice. Similar results were observed with the EtOHE from the wild species. VA significantly reduced both phases of the formalin test. This effect was partially reversed by naloxone. EtOHE from cultivated or wild A. cearensis inhibited the carrageenan (Cg)-induced mice paw edema. Furthermore, VA inhibited the paw edema and the leukocyte migration in rat peritoneal cavity induced by Cg. On the other hand, it did not inhibit the edema and the increase of vascular permeability induced by dextran in the rat paw. All together, these results indicate that the EtOHE from cultivated A. cearensis exhibit similar chemical and pharmacological profiles, as related to the wild plant. VA is, at least partially, responsible for these pharmacological effects. Its antinociceptive effect occurs by a mechanism partly dependent upon the opioid system, while the anti-inflammatory action was manifested in inflammatory processes dependent on polymorphonuclear cells and are probably related to the VA inhibition of cytokines as observed by others.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1618-095X
pubmed:author
pubmed:copyrightInfo
2010 Elsevier GmbH. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
230-3
pubmed:meshHeading
pubmed-meshheading:20638258-Analgesics, pubmed-meshheading:20638258-Animals, pubmed-meshheading:20638258-Anti-Inflammatory Agents, pubmed-meshheading:20638258-Capillary Permeability, pubmed-meshheading:20638258-Carrageenan, pubmed-meshheading:20638258-Dextrans, pubmed-meshheading:20638258-Edema, pubmed-meshheading:20638258-Fabaceae, pubmed-meshheading:20638258-Formaldehyde, pubmed-meshheading:20638258-Leukocytes, pubmed-meshheading:20638258-Male, pubmed-meshheading:20638258-Mice, pubmed-meshheading:20638258-Naloxone, pubmed-meshheading:20638258-Pain, pubmed-meshheading:20638258-Peritoneum, pubmed-meshheading:20638258-Phytotherapy, pubmed-meshheading:20638258-Plant Extracts, pubmed-meshheading:20638258-Rats, pubmed-meshheading:20638258-Rats, Wistar, pubmed-meshheading:20638258-Vanillic Acid
pubmed:year
2011
pubmed:articleTitle
A comparative chemical and pharmacological study of standardized extracts and vanillic acid from wild and cultivated Amburana cearensis A.C. Smith.
pubmed:affiliation
Department of Pharmacy, Federal University of Ceará, Rua Capitão Francisco Pedro, 1210, 60430-370 Fortaleza, Brazil. kalyne@ufc.br
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't