Source:http://linkedlifedata.com/resource/pubmed/id/20637221
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2010-8-30
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pubmed:abstractText |
The inhibitory effects of toxin extracted from muscle or liver of five different puffer fishes (hereafter referred as puffer(s)) captured on the Japanese sea coast were examined on voltage-dependent sodium current (I(Na)) recorded from dissociated single rat hippocampal CA1 neurons. The inhibitory effects estimated from IC(50) values of toxin extracts on I(Na) were in the order of Takifugu vermicularis > Lagocephalus wheeleri > Canthigaster rivulata > Takifugu rubripes > Arothron reticularis from muscle and T. vermicularis > T. rubripes > L. wheeleri > A. reticularis > C. rivulata from liver, thereby indicating that the amount of toxin in the liver or muscle differs between puffers. In addition, the present results indicate that the muscle of T. vermicularis, which is eaten in Japan, contains relatively higher amounts of toxin compared to those of T. rubripes, also eaten. This observation suggests that caution should be taken concerning the maximal edible amount of muscle prepared from T. rubripes.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1879-3150
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pubmed:author | |
pubmed:copyrightInfo |
(c) 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
999-1006
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pubmed:meshHeading |
pubmed-meshheading:20637221-Animals,
pubmed-meshheading:20637221-Cells, Cultured,
pubmed-meshheading:20637221-Hippocampus,
pubmed-meshheading:20637221-Inhibitory Concentration 50,
pubmed-meshheading:20637221-Japan,
pubmed-meshheading:20637221-Liver,
pubmed-meshheading:20637221-Muscle, Skeletal,
pubmed-meshheading:20637221-Neurons,
pubmed-meshheading:20637221-Patch-Clamp Techniques,
pubmed-meshheading:20637221-Rats,
pubmed-meshheading:20637221-Rats, Wistar,
pubmed-meshheading:20637221-Sodium Channel Blockers,
pubmed-meshheading:20637221-Sodium Channels,
pubmed-meshheading:20637221-Species Specificity,
pubmed-meshheading:20637221-Tetraodontiformes,
pubmed-meshheading:20637221-Tetrodotoxin,
pubmed-meshheading:20637221-Tissue Extracts
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pubmed:year |
2010
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pubmed:articleTitle |
Inhibition of Na currents by the toxin extracts from puffer fishes captured in the sea coast of Japan.
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pubmed:affiliation |
Research Division for Life Sciences, Kumamoto Health Science University, #325 Izumi-machi, Kumamoto city, Kumamoto Pref., 861-5598, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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