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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-11-1
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pubmed:abstractText |
Innate immune responses are crucial for host defense against pathogens but need to be tightly regulated to prevent chronic inflammation. Initial characterization of mice with a targeted inactivating mutation in the p110? subunit of phosphoinositide 3-kinase (PI3K p110?(D910A/D910A)) revealed defects in B- and T-cell signaling and chronic colitis. Here, we further characterize features of inflammatory bowel diseases in these mice and investigate underlying innate immune defects.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1528-0012
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pubmed:author |
pubmed-author:KobayashiTakuT,
pubmed-author:LiFenglingF,
pubmed-author:MatsuokaKatsuyoshiK,
pubmed-author:PlevyScott ESE,
pubmed-author:RaoKavitha NKN,
pubmed-author:SartorR BalfourRB,
pubmed-author:SepulvedaAntonia RAR,
pubmed-author:SheikhShehzad ZSZ,
pubmed-author:SteinbachErin CEC,
pubmed-author:UnoJennifer KJK,
pubmed-author:VanhaesebroeckBartB
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pubmed:copyrightInfo |
Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
139
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1642-53, 1653.e1-6
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pubmed:dateRevised |
2011-11-1
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pubmed:meshHeading |
pubmed-meshheading:20637203-Animals,
pubmed-meshheading:20637203-Chronic Disease,
pubmed-meshheading:20637203-Colitis,
pubmed-meshheading:20637203-Colon,
pubmed-meshheading:20637203-Disease Models, Animal,
pubmed-meshheading:20637203-Disease Progression,
pubmed-meshheading:20637203-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:20637203-Gene Expression,
pubmed-meshheading:20637203-Immunity, Innate,
pubmed-meshheading:20637203-Macrophages,
pubmed-meshheading:20637203-Mice,
pubmed-meshheading:20637203-Mice, Inbred C57BL,
pubmed-meshheading:20637203-Phosphatidylinositol 3-Kinase,
pubmed-meshheading:20637203-Polymerase Chain Reaction,
pubmed-meshheading:20637203-RNA
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pubmed:year |
2010
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pubmed:articleTitle |
Altered macrophage function contributes to colitis in mice defective in the phosphoinositide-3 kinase subunit p110?.
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pubmed:affiliation |
Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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