Source:http://linkedlifedata.com/resource/pubmed/id/20637184
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2010-9-3
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| pubmed:abstractText |
Telmisartan, an angiotensin type 1 receptor blocker (ARB), is used for hypertension to control blood pressure and has been shown to have a partial agonistic effect on peroxisome proliferator-activated receptor gamma (PPARgamma). Recently, the ligand of PPARgamma has been implicated in cerebroprotection due to its anti-inflammatory effect. In this study, we investigated whether telmisartan has a cerebroprotective effect on memory impairment and neuronal cell death induced by repeated cerebral ischemia. Repeated cerebral ischemia (RI: 10 min x 2) significantly induced impairment of spatial memory and hippocampal apoptosis in rats. Fourteen-day pre- and post-ischemic administration of telmisartan (0.3, 1, 3mg/kg/day, p.o.) increased the number of correct choices and reduced the number of errors made in the eight-arm radial maze task in a dose-dependent manner in RI treated rats. TUNEL-positive cells in the hippocampus CA1 areas were also reduced following 14-day administration of telmisartan (3mg/kg/day, p.o.). Seven-day post-ischemic administration of telmisartan improved spatial memory and reduced TUNEL-positive cells while 7-day pre-ischemic administration of telmisartan did not. These effects of telmisartan were inhibited by the PPARgamma antagonist, GW9662. On further experiment, 7-day post-ischemic administration of telmisartan reduced the expression of caspase-3 in the hippocampus, and this effect was also inhibited by GW9662. These results suggest that telmisartan improves memory impairment and reduces neuronal apoptosis via a PPARgamma-dependent caspase-3 inhibiting mechanism. Telmisartan, which has the unique character of having both ARB and PPARgamma agonistic effect, will be useful for preventing memory impairment after cerebrovascular disease.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-chloro-5-nitrobenzanilide,
http://linkedlifedata.com/resource/pubmed/chemical/Anilides,
http://linkedlifedata.com/resource/pubmed/chemical/Benzimidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoates,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/PPAR gamma,
http://linkedlifedata.com/resource/pubmed/chemical/telmisartan
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
1872-6240
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| pubmed:author |
pubmed-author:FujiwaraMichihiroM,
pubmed-author:HaraguchiTamamiT,
pubmed-author:IwasakiKatsunoriK,
pubmed-author:KatsurabayashiShutaroS,
pubmed-author:KubotaKaoriK,
pubmed-author:MishimaKenichiK,
pubmed-author:NaitoTetsuyaT,
pubmed-author:NishimuraRyojiR,
pubmed-author:NogamiAiA,
pubmed-author:ShindoTaroT,
pubmed-author:TakasakiKotaroK,
pubmed-author:UchidaKanakoK,
pubmed-author:UchidaNaokiN
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| pubmed:copyrightInfo |
Copyright 2010 Elsevier B.V. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:day |
24
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| pubmed:volume |
1353
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
125-32
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| pubmed:meshHeading |
pubmed-meshheading:20637184-Analysis of Variance,
pubmed-meshheading:20637184-Anilides,
pubmed-meshheading:20637184-Animals,
pubmed-meshheading:20637184-Apoptosis,
pubmed-meshheading:20637184-Benzimidazoles,
pubmed-meshheading:20637184-Benzoates,
pubmed-meshheading:20637184-Brain Ischemia,
pubmed-meshheading:20637184-Caspase 3,
pubmed-meshheading:20637184-Dose-Response Relationship, Drug,
pubmed-meshheading:20637184-Hippocampus,
pubmed-meshheading:20637184-In Situ Nick-End Labeling,
pubmed-meshheading:20637184-Male,
pubmed-meshheading:20637184-Maze Learning,
pubmed-meshheading:20637184-Memory Disorders,
pubmed-meshheading:20637184-PPAR gamma,
pubmed-meshheading:20637184-Rats,
pubmed-meshheading:20637184-Rats, Wistar,
pubmed-meshheading:20637184-Spatial Behavior,
pubmed-meshheading:20637184-Time Factors
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| pubmed:year |
2010
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| pubmed:articleTitle |
Telmisartan, a partial agonist of peroxisome proliferator-activated receptor gamma, improves impairment of spatial memory and hippocampal apoptosis in rats treated with repeated cerebral ischemia.
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| pubmed:affiliation |
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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