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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2010-11-2
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pubmed:abstractText |
The hygiene hypothesis states that early exposure to bacterial products such as lipopolysaccharide (LPS) may be protective against the development of allergic diseases. Whether atopic disease affects the ability of immune cells to respond to LPS is unclear. Our laboratory has demonstrated previously that children express high levels of Toll-like receptor (TLR)-4 on CD4(+) cells in nasal mucosa.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD14,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP...,
http://linkedlifedata.com/resource/pubmed/chemical/IL4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/TLR4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 4,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1365-2222
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pubmed:author |
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pubmed:copyrightInfo |
© 2010 Blackwell Publishing Ltd.
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pubmed:issnType |
Electronic
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1648-57
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pubmed:meshHeading |
pubmed-meshheading:20636402-Adolescent,
pubmed-meshheading:20636402-Adult,
pubmed-meshheading:20636402-Antigens, CD14,
pubmed-meshheading:20636402-Antigens, CD3,
pubmed-meshheading:20636402-Antigens, CD4,
pubmed-meshheading:20636402-Case-Control Studies,
pubmed-meshheading:20636402-Child,
pubmed-meshheading:20636402-Child, Preschool,
pubmed-meshheading:20636402-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:20636402-Flow Cytometry,
pubmed-meshheading:20636402-Humans,
pubmed-meshheading:20636402-Hypersensitivity,
pubmed-meshheading:20636402-Immunity, Innate,
pubmed-meshheading:20636402-Interleukin-4,
pubmed-meshheading:20636402-Lipopolysaccharides,
pubmed-meshheading:20636402-Middle Aged,
pubmed-meshheading:20636402-Monocytes,
pubmed-meshheading:20636402-Phosphorylation,
pubmed-meshheading:20636402-Quebec,
pubmed-meshheading:20636402-Signal Transduction,
pubmed-meshheading:20636402-Toll-Like Receptor 4,
pubmed-meshheading:20636402-Young Adult,
pubmed-meshheading:20636402-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2010
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pubmed:articleTitle |
Children with atopic histories exhibit impaired lipopolysaccharide-induced Toll-like receptor-4 signalling in peripheral monocytes.
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pubmed:affiliation |
Meakins Christie Laboratories and Montreal Children's Hospital Research Institute, McGill University Health Center Research Institute, Montreal, QC, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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