Source:http://linkedlifedata.com/resource/pubmed/id/20636287
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2011-2-10
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| pubmed:abstractText |
Although errant saccadic eye movements may mark genetic factors in schizophrenia, little is known about abnormal brain activity that precedes saccades in individuals with genetic liability for schizophrenia. We investigated electrophysiological activity preceding prosaccades and antisaccades in schizophrenia patients, first-degree biological relatives of schizophrenia patients, and control subjects. Prior to antisaccades, patients had reduced potentials over lateral prefrontal cortex. Smaller potentials were associated with worse antisaccade performance. Relatives also exhibited reduced pre-saccadic potentials over lateral frontal cortex but additionally had reduced potentials over parietal cortex. Both patients and relatives tended toward increased activity over orbital frontal cortex prior to saccades. Results are consistent with lateral prefrontal dysfunction marking genetic liability for schizophrenia and underlying deficient saccadic control.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
1540-5958
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| pubmed:author | |
| pubmed:copyrightInfo |
Journal compilation © 2010 Society for Psychophysiological Research. No claim to original US government works.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
48
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
350-61
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| pubmed:meshHeading |
pubmed-meshheading:20636287-Adult,
pubmed-meshheading:20636287-Antipsychotic Agents,
pubmed-meshheading:20636287-Data Interpretation, Statistical,
pubmed-meshheading:20636287-Diagnostic and Statistical Manual of Mental Disorders,
pubmed-meshheading:20636287-Electroencephalography,
pubmed-meshheading:20636287-Electrophysiological Phenomena,
pubmed-meshheading:20636287-Female,
pubmed-meshheading:20636287-Fixation, Ocular,
pubmed-meshheading:20636287-Humans,
pubmed-meshheading:20636287-Male,
pubmed-meshheading:20636287-Middle Aged,
pubmed-meshheading:20636287-Parietal Lobe,
pubmed-meshheading:20636287-Photic Stimulation,
pubmed-meshheading:20636287-Prefrontal Cortex,
pubmed-meshheading:20636287-Reaction Time,
pubmed-meshheading:20636287-Saccades,
pubmed-meshheading:20636287-Schizophrenia,
pubmed-meshheading:20636287-Schizophrenic Psychology
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| pubmed:year |
2011
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| pubmed:articleTitle |
Abnormal mechanisms of antisaccade generation in schizophrenia patients and unaffected biological relatives of schizophrenia patients.
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| pubmed:affiliation |
Department of Psychology, University of Minnesota, Twin Cities, Minnesota Department of Psychiatry, University of Minnesota, Twin Cities, Minnesota Veterans Affairs Medical Center, Minneapolis, Minnesota, USA.
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| pubmed:publicationType |
Journal Article
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