Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-7-19
pubmed:abstractText
Cancer stem-like cells (CSCs)/tumor-initiating cells (TICs) are a small population of cancer cells that have the properties of tumor-initiating ability, self-renewal and differentiation. These properties suggest that CSCs/TICs are essential for tumor maintenance, recurrence and distant metastasis. Thus, elimination of CSCs/TICs is essential to cure malignant diseases. However, there are several studies reporting that CSCs/TICs are more resistant to standard cancer therapies, including chemotherapy and radiotherapy, than non-CSC/TIC populations. How then, can we eliminate CSCs/TICs? Immunotherapy might be the possible answer. In recent analysis, innate immunity (natural killer cells and gammadeltaT cells) and also adaptive immunity (cytotoxic T lymphocyte-based cellular immunity and antibody-based humoral immunity) can recognize CSCs/TICs in vitro efficiently. Furthermore, CSC/TIC-specific monoclonal antibody therapies are also efficient in vivo. In this article, we describe the potency, possibilities and problems of CSC/TIC-targeting immunotherapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1750-7448
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
201-11
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:20635928-Adaptive Immunity, pubmed-meshheading:20635928-Aldehyde Dehydrogenase, pubmed-meshheading:20635928-Antibodies, Neoplasm, pubmed-meshheading:20635928-Antigens, Neoplasm, pubmed-meshheading:20635928-Antigens, Surface, pubmed-meshheading:20635928-Feasibility Studies, pubmed-meshheading:20635928-Forecasting, pubmed-meshheading:20635928-Humans, pubmed-meshheading:20635928-Immunity, Innate, pubmed-meshheading:20635928-Immunotherapy, pubmed-meshheading:20635928-Isoenzymes, pubmed-meshheading:20635928-Killer Cells, Natural, pubmed-meshheading:20635928-Models, Biological, pubmed-meshheading:20635928-Neoplasms, pubmed-meshheading:20635928-Neoplastic Stem Cells, pubmed-meshheading:20635928-Retinal Dehydrogenase, pubmed-meshheading:20635928-T-Lymphocyte Subsets, pubmed-meshheading:20635928-T-Lymphocytes, Cytotoxic, pubmed-meshheading:20635928-Tumor Markers, Biological
pubmed:year
2010
pubmed:articleTitle
Immune response against tumor antigens expressed on human cancer stem-like cells/tumor-initiating cells.
pubmed:affiliation
Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.
pubmed:publicationType
Journal Article, Review