Linked Life Data

20634811

Source:http://linkedlifedata.com/resource/pubmed/id/20634811

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2010-7-16
pubmed:abstractText
The divergence of new genes and proteins occurs through mutations that modulate protein function. However, mutations are pleiotropic and can have different effects on organismal fitness depending on the environment, as well as opposite effects on protein function and dosage. We review the pleiotropic effects of mutations. We discuss how they affect the evolution of gene and protein function, and how these complex mutational effects dictate the likelihood and mechanism of gene duplication and divergence. We propose several factors that can affect the divergence of new protein functions, including mutational trade-offs and hidden, or apparently neutral, variation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1471-0064
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
572-82
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Mutational effects and the evolution of new protein functions.
pubmed:affiliation
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't