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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-11-5
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pubmed:abstractText |
Macrophage scavenger receptor A (SR-A) and class B scavenger receptor CD36 (CD36) contribute to foam cell formation and atherogenesis via uptake of modified lipoproteins. So far, the role of these scavenger receptors has been studied mainly using knockout models totally lacking these receptors. We studied the role of SR-A and CD36 in foam cell formation and atherogenesis by RNA interference (RNAi)-mediated silencing, which is a clinically feasible method to down-regulate the expression of these receptors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1755-3245
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
530-8
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pubmed:meshHeading |
pubmed-meshheading:20634212-Animals,
pubmed-meshheading:20634212-Antigens, CD36,
pubmed-meshheading:20634212-Apolipoproteins B,
pubmed-meshheading:20634212-Atherosclerosis,
pubmed-meshheading:20634212-Cell Line,
pubmed-meshheading:20634212-Disease Models, Animal,
pubmed-meshheading:20634212-Female,
pubmed-meshheading:20634212-Foam Cells,
pubmed-meshheading:20634212-Humans,
pubmed-meshheading:20634212-Hyperlipidemias,
pubmed-meshheading:20634212-Lentivirus,
pubmed-meshheading:20634212-Macrophages,
pubmed-meshheading:20634212-Male,
pubmed-meshheading:20634212-Mice,
pubmed-meshheading:20634212-Mice, Knockout,
pubmed-meshheading:20634212-RNA Interference,
pubmed-meshheading:20634212-Receptors, LDL,
pubmed-meshheading:20634212-Scavenger Receptors, Class A,
pubmed-meshheading:20634212-Up-Regulation
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pubmed:year |
2010
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pubmed:articleTitle |
Silencing of either SR-A or CD36 reduces atherosclerosis in hyperlipidaemic mice and reveals reciprocal upregulation of these receptors.
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pubmed:affiliation |
Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, PO Box 1627, 70211 Kuopio, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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