Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2010-9-29
pubmed:abstractText
Enteric nervous system (ENS) development is relevant to Hirschsprung's disease (HSCR; congenital aganglionosis of the terminal bowel), which is still imperfectly treated. Mutations in genes encoding the RET receptor tyrosine kinase and endothelin receptor type B (EDNRB) are involved in HSCR pathogenesis; however, also important in ENS development are molecules that mediate events that are more restricted than those of RET and EDNRB, act later in development and which might not be HSCR-associated. Examples are molecules that function in the guidance of enteric neural crest-derived cells (ENCDCs) and vagal axons, and in regulating the terminal differentiation of enteric neurons from ENCDCs. It is probable that highly prevalent disorders of gastrointestinal sensation and motility result from subtle defects in ENS development.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1878-108X
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
446-56
pubmed:meshHeading
pubmed-meshheading:20633936-Cell Differentiation, pubmed-meshheading:20633936-Cell Movement, pubmed-meshheading:20633936-Endothelin-3, pubmed-meshheading:20633936-Enteric Nervous System, pubmed-meshheading:20633936-Extracellular Matrix, pubmed-meshheading:20633936-Ganglia, Autonomic, pubmed-meshheading:20633936-Gastrointestinal Tract, pubmed-meshheading:20633936-Glial Cell Line-Derived Neurotrophic Factor, pubmed-meshheading:20633936-Glial Cell Line-Derived Neurotrophic Factor Receptors, pubmed-meshheading:20633936-Hirschsprung Disease, pubmed-meshheading:20633936-Humans, pubmed-meshheading:20633936-Mutation, pubmed-meshheading:20633936-Nerve Growth Factors, pubmed-meshheading:20633936-Neural Crest, pubmed-meshheading:20633936-Neurons, pubmed-meshheading:20633936-Proto-Oncogene Proteins c-ret, pubmed-meshheading:20633936-Risk Factors, pubmed-meshheading:20633936-Tumor Suppressor Proteins
pubmed:year
2010
pubmed:articleTitle
Developmental determinants of the independence and complexity of the enteric nervous system.
pubmed:affiliation
Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA. mdg4@columbia.edu
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural