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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2010-9-13
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pubmed:abstractText |
Based on experimental findings, overexpression of P-glycoprotein at the blood-brain barrier has been suggested to be a contributor to pharmacoresistance of the epileptic brain. We test a technique for evaluation of interindividual differences of elevated transporter function, through microPET analysis of the impact of the P-glycoprotein modulator tariquidar. The preclinical study is intended for eventual translation to clinical research of patients with pharmacoresistant seizure disorders.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1528-1167
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pubmed:author |
pubmed-author:BöningGuidoG,
pubmed-author:BartensteinPeterP,
pubmed-author:BartmannHeroH,
pubmed-author:CummingPaulP,
pubmed-author:FuestChristinaC,
pubmed-author:JustTheresaT,
pubmed-author:PekcecAntonA,
pubmed-author:PotschkaHeidrunH,
pubmed-author:SchlichtigerJuliJ,
pubmed-author:SoerensenJonnaJ,
pubmed-author:WänglerBjörnB,
pubmed-author:WinterPetraP,
pubmed-author:XiongGuomingG,
pubmed-author:la FougereChristianC
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pubmed:copyrightInfo |
Wiley Periodicals, Inc. © 2010 International League Against Epilepsy.
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pubmed:issnType |
Electronic
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1780-90
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pubmed:meshHeading |
pubmed-meshheading:20633036-Animals,
pubmed-meshheading:20633036-Blood-Brain Barrier,
pubmed-meshheading:20633036-Brain,
pubmed-meshheading:20633036-Carbon Radioisotopes,
pubmed-meshheading:20633036-Disease Models, Animal,
pubmed-meshheading:20633036-Drug Resistance, Multiple,
pubmed-meshheading:20633036-Epilepsy, Temporal Lobe,
pubmed-meshheading:20633036-Hippocampus,
pubmed-meshheading:20633036-Humans,
pubmed-meshheading:20633036-P-Glycoprotein,
pubmed-meshheading:20633036-Phenobarbital,
pubmed-meshheading:20633036-Positron-Emission Tomography,
pubmed-meshheading:20633036-Quinolines,
pubmed-meshheading:20633036-Rats,
pubmed-meshheading:20633036-Rats, Sprague-Dawley,
pubmed-meshheading:20633036-Seizures
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pubmed:year |
2010
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pubmed:articleTitle |
Imaging of P-glycoprotein-mediated pharmacoresistance in the hippocampus: proof-of-concept in a chronic rat model of temporal lobe epilepsy.
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pubmed:affiliation |
Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig-Maximilians-University, Munich, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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