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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2010-10-11
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pubmed:abstractText |
The study of genes involved in androgen pathway can contribute to a better knowledge of prostate cancer. Our aim was to examine if polymorphisms in prostate-specific antigen (PSA) and androgen receptor (AR) genes were involved in prostate cancer risk and aggressiveness. Genotypes were determined by PCR-RFLP (PSA) or using a 377 ABI DNA Sequencer (AR). PSA(G/G) genotype (OR = 1.78, 95% CI = 1.06–2.99) and AR short CAG repeats (OR = 1.89, 95% CI = 1.21–2.96) increased risk for prostate cancer and were related with tumor aggressiveness. About 38.3% of tumors showed microsatellite instability. In conclusion, polymorphisms in these genes may be indicated as potential biomarkers for prostate cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1532-4192
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
917-24
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pubmed:meshHeading |
pubmed-meshheading:20632874-Aged,
pubmed-meshheading:20632874-Alleles,
pubmed-meshheading:20632874-Gene Frequency,
pubmed-meshheading:20632874-Genetic Predisposition to Disease,
pubmed-meshheading:20632874-Genotype,
pubmed-meshheading:20632874-Humans,
pubmed-meshheading:20632874-Male,
pubmed-meshheading:20632874-Middle Aged,
pubmed-meshheading:20632874-Neoplasm Invasiveness,
pubmed-meshheading:20632874-Polymerase Chain Reaction,
pubmed-meshheading:20632874-Polymorphism, Genetic,
pubmed-meshheading:20632874-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:20632874-Prostate-Specific Antigen,
pubmed-meshheading:20632874-Prostatic Neoplasms,
pubmed-meshheading:20632874-Receptors, Androgen,
pubmed-meshheading:20632874-Sequence Analysis, DNA,
pubmed-meshheading:20632874-Trinucleotide Repeats,
pubmed-meshheading:20632874-Tumor Markers, Biological
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pubmed:year |
2010
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pubmed:articleTitle |
Polymorphisms in the AR and PSA genes as markers of susceptibility and aggressiveness in prostate cancer.
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pubmed:affiliation |
Department of General Biology, Biological Science Center, Londrina State University, Paraná, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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