|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2010-11-5
|
|
pubmed:abstractText |
Endothelial progenitor cells (EPC) have been shown to repair pulmonary endothelium, although they can also migrate into the arterial intima and differentiate into smooth muscle-like (mesenchymal) cells contributing to intimal hyperplasia. The molecular mechanisms by which this process proceeds have not been fully elucidated. Here, we study whether genes involved in the endothelial-to-mesenchymal transition (EnMT) may contribute to the mesenchymal phenotype acquisition of EPC and we evaluate whether transforming growth factor ?1 (TGF?1) is involved in this process.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Endothelin A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Transforming Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/TGF-beta type I receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/cadherin 5,
http://linkedlifedata.com/resource/pubmed/chemical/snail family transcription factors
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
1755-3245
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
1
|
|
pubmed:volume |
88
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
502-11
|
|
pubmed:meshHeading |
pubmed-meshheading:20631156-Actins,
pubmed-meshheading:20631156-Antigens, CD,
pubmed-meshheading:20631156-Cadherins,
pubmed-meshheading:20631156-Cell Differentiation,
pubmed-meshheading:20631156-Cell Proliferation,
pubmed-meshheading:20631156-Cells, Cultured,
pubmed-meshheading:20631156-Endothelin-1,
pubmed-meshheading:20631156-Endothelium, Vascular,
pubmed-meshheading:20631156-Hematopoietic Stem Cells,
pubmed-meshheading:20631156-Humans,
pubmed-meshheading:20631156-Mesoderm,
pubmed-meshheading:20631156-Muscle, Smooth, Vascular,
pubmed-meshheading:20631156-Phenotype,
pubmed-meshheading:20631156-Protein-Serine-Threonine Kinases,
pubmed-meshheading:20631156-Receptor, Endothelin A,
pubmed-meshheading:20631156-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:20631156-Transcription Factors
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Endothelial progenitor cells undergo an endothelial-to-mesenchymal transition-like process mediated by TGFbetaRI.
|
|
pubmed:affiliation |
Department of Pulmonary Medicine, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Ciber de Enfermedades Respiratorias, Universitat de Barcelona, Barcelona, Spain.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
