|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006826,
umls-concept:C0162638,
umls-concept:C0205112,
umls-concept:C0205210,
umls-concept:C0205263,
umls-concept:C0234402,
umls-concept:C0332282,
umls-concept:C0681842,
umls-concept:C0750572,
umls-concept:C1516044,
umls-concept:C1521828,
umls-concept:C1709630
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|
pubmed:issue |
17
|
|
pubmed:dateCreated |
2010-9-2
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|
pubmed:abstractText |
We hypothesized that the basal apoptotic rate (BAR) of a cancer would predict sensitivity to subsequent proapoptotic stimuli. To explore this, preclinical and clinical BAR assays were developed measuring cumulative apoptotic events through ELISAs for soluble caspase-cleaved cytokeratin 18 (M30) normalized to either cell number increase or total tumor volume, respectively.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1078-0432
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
1
|
|
pubmed:volume |
16
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
4478-89
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pubmed:meshHeading |
pubmed-meshheading:20630997-Adult,
pubmed-meshheading:20630997-Aged,
pubmed-meshheading:20630997-Aged, 80 and over,
pubmed-meshheading:20630997-Amino Acid Chloromethyl Ketones,
pubmed-meshheading:20630997-Apoptosis,
pubmed-meshheading:20630997-Blotting, Western,
pubmed-meshheading:20630997-Caspase 3,
pubmed-meshheading:20630997-Cell Line, Tumor,
pubmed-meshheading:20630997-Cell Proliferation,
pubmed-meshheading:20630997-Cysteine Proteinase Inhibitors,
pubmed-meshheading:20630997-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:20630997-Female,
pubmed-meshheading:20630997-Humans,
pubmed-meshheading:20630997-Immunoblotting,
pubmed-meshheading:20630997-In Situ Nick-End Labeling,
pubmed-meshheading:20630997-Keratin-18,
pubmed-meshheading:20630997-Male,
pubmed-meshheading:20630997-Middle Aged,
pubmed-meshheading:20630997-Neoplasms,
pubmed-meshheading:20630997-Prognosis,
pubmed-meshheading:20630997-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:20630997-RNA Interference,
pubmed-meshheading:20630997-Signal Transduction,
pubmed-meshheading:20630997-Tumor Suppressor Protein p53,
pubmed-meshheading:20630997-X-Linked Inhibitor of Apoptosis Protein
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|
pubmed:year |
2010
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|
pubmed:articleTitle |
Preclinical and clinical estimates of the basal apoptotic rate of a cancer predict the amount of apoptosis induced by subsequent proapoptotic stimuli.
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|
pubmed:affiliation |
Department of Pharmacology, University of Colorado, School of Medicine, Aurora, CO, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
