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rdf:type |
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lifeskim:mentions |
umls-concept:C0013786,
umls-concept:C0032718,
umls-concept:C0033554,
umls-concept:C0034493,
umls-concept:C0391871,
umls-concept:C0439659,
umls-concept:C0521390,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
1978-7-15
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pubmed:abstractText |
Transmural electrical stimulation of the isolated portal vein of the rabbit was accompanied by the release of a prostaglandin-like substance (PLS). Thin layer chromatography coupled with bioassay indicated that this substance was probably prostaglandin E2 (PGE2). 2 Indomethacin potentiated the response of the portal vein to electrical stimulation at 2 Hz and abolished the release of the PLS. 3 There was no significant change in the amount of PLS released from the portal vein in response to electrical stimulation at 2 Hz when the contractile response of the portal vein was prevented by pretreatment with phentolamine or guanthidine. 4 In vitro denervation of the portal vein with 6-hydroxydopamine or the omission of Ca2+ from the bathing solution caused a significant reduction in the amount of PLS released from the portal vein in response to electrical stimulation at 2 hertz. 5 It is concluded that electrical stimulation of the isolated portal vein of the rabbit is accompanied by the release of a PLS, probably PGE2, from a neuronal source. The synthesis and release of the PLS is Ca2+ -dependent.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/206308-194531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/206308-4106477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/206308-4329800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/206308-4332404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/206308-4337119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/206308-4339251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/206308-4359555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/206308-4451810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/206308-4629615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/206308-4674334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/206308-4724995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/206308-4966506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/206308-5286094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/206308-5656636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/206308-978460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/206308-978461
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
79-85
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:206308-Animals,
pubmed-meshheading:206308-Calcium,
pubmed-meshheading:206308-Denervation,
pubmed-meshheading:206308-Electric Stimulation,
pubmed-meshheading:206308-Guanethidine,
pubmed-meshheading:206308-Indomethacin,
pubmed-meshheading:206308-Male,
pubmed-meshheading:206308-Neuromuscular Junction,
pubmed-meshheading:206308-Neurosecretion,
pubmed-meshheading:206308-Phentolamine,
pubmed-meshheading:206308-Portal Vein,
pubmed-meshheading:206308-Prostaglandins,
pubmed-meshheading:206308-Rabbits,
pubmed-meshheading:206308-Synaptic Transmission
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pubmed:year |
1978
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pubmed:articleTitle |
The neuronal origin of prostaglandin released from the rabbit portal vein in response to electrical stimulation.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro
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