Linked Life Data

206306

Source:http://linkedlifedata.com/resource/pubmed/id/206306

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1978-7-15
pubmed:abstractText
1 Graded motor responses were elicited in isolated, desheathed, thin strips of dog, horse, pig and sheep retractor penis (RP) muscles by field stimulation with trains of 0.2 ms pulses at 10 hertz. These twitches were shown to be neurogenic in all four species, by their prompt extinction in tetrodotoxin.2 alpha-Adrenoceptor blocking drugs abolished the contractile response to noradrenaline and to tyramine in all four species.3 Motor transmission was wholly adrenergic in the horse as in the dog RP because phentolamine rapidly abolished the electrically induced twitches in both these species; but in the pig and in the sheep RP a large proportion of the motor transmission was unaffected by phentolamine given in many times the concentration required to abolish matching noradrenaline-induced contractions.4 Because of the occurrence of periodic spasms in sheep preparations, further investigation of the phentolamine-resistant transmission was confined to the pig RP. Its responses were shown to be entirely postganglionic in origin because they were unaffected by pentolinium.5 In the pig RP a considerable proportion of the phentolamine-resistant motor transmission persisted after combined blockade of alpha- and beta-adrenoceptors by phenoxybenzamine plus propranolol and was more resistant to guanethidine and bretylium than the motor transmission to the dog RP; it was not extinguished after reserpine treatment.6 The pig RP is contracted by histamine but is rather insensitive to acetylcholine, 5-hydroxytryptamine and adenosine-5'-triphosphate. The motor transmission remained unaffected after responses to these substances were blocked by the following antagonists, given alone or in combination: mepyramine, burimamide, atropine, (+)-tubocurarine, methysergide and 2-2'-pyridylisatogen tosylate.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
25-34
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Species of differences in postganglionic motor transmission to the retractor penis muscle.
pubmed:publicationType
Journal Article, Comparative Study