Source:http://linkedlifedata.com/resource/pubmed/id/20627581
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
|
pubmed:dateCreated |
2010-7-19
|
pubmed:abstractText |
We examined the effects of the phosphodiesterase 5 (PDE-5) inhibitor vardenafil on cerebral vasospasm in an experimental rat subarachnoid hemorrhage (SAH) model. Thirty-two albino Wistar rats were divided into five groups: G1, no experimental intervention; G2, administered subarachnoid physiological saline after sham surgery; G3, subjected to SAH; G4, subjected to SAH and administered low-dose (0.5 mg/kg) vardenafil treatment; and G5, subjected to SAH and administered high-dose (5 mg/kg) vardenafil treatment. For animals in G3, G4 and G5, SAH was induced by an injection of autologous non-heparinized blood into the cisterna magna. Immediately after SAH, for animals in G4 and G5, vardenafil was administered by gavage at intervals of 8 hours for 2 days. The rats were then decapitated, and basilar arteries and blood samples were taken for biochemical and histopathological examination. Malonyldialdehyde values in G2 (p = 0.004) and G3 (p = 0.002) were significantly higher than those in G1. G4 and G5 had significantly lower values than G2 and G3 (p = 0.014, G4 v. G2; p = 0.005, G4 v. G3; p = 0.005, G5 v. G2; p = 0.002, G5 v. G3). Total antioxidant capacity (TAC) values in G3 were significantly lower than those in G1 (p = 0.041). TAC values in G4 and G5 were significantly higher than those in G3 (p = 0.043). Mean luminal diameter in G3 was significantly smaller compared with G1 and G2 (p = 0.002), but larger in G4 (p = 0.002) and G5 (p = 0.001) compared with G3. Mean luminal diameter was also significantly larger in G5 than in G2 (p = 0.008) and G4 (p = 0.038). Mean wall thickness in G2 (p = 0.015) and G3 (p = 0.002) was significantly thicker compared with G1. Wall thickness was significantly thinner in G4 and G5 compared with G2 and G3 (p = 0.008, G4 v. G2; p = 0.001, G4 v. G3; p = 0.005, G5 v. G2; p = 0.001, G5 v. G3). Our results confirm that vardenafil may induce vasodilatation and provide potential benefits in SAH therapy by preventing vasospasm.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Malondialdehyde,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfones,
http://linkedlifedata.com/resource/pubmed/chemical/Triazines,
http://linkedlifedata.com/resource/pubmed/chemical/vardenafil
|
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
1532-2653
|
pubmed:author | |
pubmed:issnType |
Electronic
|
pubmed:volume |
17
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1038-41
|
pubmed:meshHeading |
pubmed-meshheading:20627581-Animals,
pubmed-meshheading:20627581-Cerebral Cortex,
pubmed-meshheading:20627581-Dose-Response Relationship, Drug,
pubmed-meshheading:20627581-Imidazoles,
pubmed-meshheading:20627581-Malondialdehyde,
pubmed-meshheading:20627581-Phosphodiesterase Inhibitors,
pubmed-meshheading:20627581-Piperazines,
pubmed-meshheading:20627581-Rats,
pubmed-meshheading:20627581-Rats, Wistar,
pubmed-meshheading:20627581-Subarachnoid Hemorrhage,
pubmed-meshheading:20627581-Sulfones,
pubmed-meshheading:20627581-Triazines,
pubmed-meshheading:20627581-Vasospasm, Intracranial
|
pubmed:year |
2010
|
pubmed:articleTitle |
Effect of vardenafil on cerebral vasospasm following experimental subarachnoid hemorrhage in rats.
|
pubmed:affiliation |
Department of Neurosurgery, School of Medicine, Zonguldak Karaelmas University, Kozlu, Zonguldak 67600, Turkey. drsanser@yahoo.com
|
pubmed:publicationType |
Journal Article
|