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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-7-14
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pubmed:abstractText |
The Wnt/beta-catenin pathway is evolutionary conserved signaling system that regulates cell differentiation and organogenesis. We show that endothelial specific stabilization of Wnt/beta-catenin signaling alters early vascular development in the embryo. The phenotype resembles that induced by upregulation of Notch signaling, including lack of vascular remodeling, altered elongation of the intersomitic vessels, defects in branching, and loss of venous identity. Both in vivo and in vitro data show that beta-catenin upregulates Dll4 transcription and strongly increases Notch signaling in the endothelium, leading to functional and morphological alterations. The functional consequences of beta-catenin signaling depend on the stage of vascular development and are lost when a gain-of-function mutation is induced at a late stage of development or postnatally. Our findings establish a link between Wnt and Notch signaling in vascular development. We propose that early and sustained beta-catenin signaling prevents correct endothelial cell differentiation, altering vascular remodeling and arteriovenous specification.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Catnb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/DLL4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Notch1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Notch1,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt1 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1878-1551
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
938-49
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pubmed:meshHeading |
pubmed-meshheading:20627076-Animals,
pubmed-meshheading:20627076-Arteries,
pubmed-meshheading:20627076-Cell Differentiation,
pubmed-meshheading:20627076-Cell Proliferation,
pubmed-meshheading:20627076-Cells, Cultured,
pubmed-meshheading:20627076-Endothelial Cells,
pubmed-meshheading:20627076-Gene Expression Regulation, Developmental,
pubmed-meshheading:20627076-Humans,
pubmed-meshheading:20627076-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:20627076-Membrane Proteins,
pubmed-meshheading:20627076-Mice,
pubmed-meshheading:20627076-Mice, Inbred C57BL,
pubmed-meshheading:20627076-Mice, Knockout,
pubmed-meshheading:20627076-Mice, Transgenic,
pubmed-meshheading:20627076-Neovascularization, Physiologic,
pubmed-meshheading:20627076-Receptor, Notch1,
pubmed-meshheading:20627076-Signal Transduction,
pubmed-meshheading:20627076-Transcriptional Activation,
pubmed-meshheading:20627076-Up-Regulation,
pubmed-meshheading:20627076-Veins,
pubmed-meshheading:20627076-Wnt1 Protein,
pubmed-meshheading:20627076-beta Catenin
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pubmed:year |
2010
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pubmed:articleTitle |
The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling.
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pubmed:affiliation |
IFOM, The FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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