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rdf:type |
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lifeskim:mentions |
umls-concept:C0015663,
umls-concept:C0021852,
umls-concept:C0024485,
umls-concept:C0036751,
umls-concept:C0043047,
umls-concept:C0061851,
umls-concept:C0231491,
umls-concept:C0376674,
umls-concept:C0456205,
umls-concept:C1280500,
umls-concept:C1516048,
umls-concept:C1550605
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pubmed:issue |
5
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pubmed:dateCreated |
2010-8-31
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pubmed:abstractText |
5-HT(3) antagonists have been shown to be effective in relieving the symptoms of irritable bowel syndrome with diarrhoea (IBS-D). Using a recently validated magnetic resonance imaging (MRI) method, we have demonstrated reduced fasting small bowel water content (SBWC) in IBS-D associated with accelerated small bowel transit. We hypothesized that slowing of transit with ondansetron would lead to an increase in SBWC by inhibiting fasting motility.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1365-2036
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pubmed:author |
pubmed-author:ArmstrongAA,
pubmed-author:BlackshawEE,
pubmed-author:BuskGG,
pubmed-author:FoleySS,
pubmed-author:GowlandP APA,
pubmed-author:HartleyCC,
pubmed-author:LOEBM XMX,
pubmed-author:ManbyPP,
pubmed-author:MarcianoJJ,
pubmed-author:PerkinsA CAC,
pubmed-author:SpillerR CRC,
pubmed-author:TotmanJ JJJ,
pubmed-author:WrightJJ
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pubmed:copyrightInfo |
2010 Blackwell Publishing Ltd.
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pubmed:issnType |
Electronic
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
655-63
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pubmed:meshHeading |
pubmed-meshheading:20626735-Adolescent,
pubmed-meshheading:20626735-Adult,
pubmed-meshheading:20626735-Aged,
pubmed-meshheading:20626735-Diarrhea,
pubmed-meshheading:20626735-Fasting,
pubmed-meshheading:20626735-Female,
pubmed-meshheading:20626735-Humans,
pubmed-meshheading:20626735-Irritable Bowel Syndrome,
pubmed-meshheading:20626735-Magnetic Resonance Imaging,
pubmed-meshheading:20626735-Male,
pubmed-meshheading:20626735-Manometry,
pubmed-meshheading:20626735-Middle Aged,
pubmed-meshheading:20626735-Ondansetron,
pubmed-meshheading:20626735-Postprandial Period,
pubmed-meshheading:20626735-Serotonin Antagonists,
pubmed-meshheading:20626735-Treatment Outcome,
pubmed-meshheading:20626735-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Effects of a 5-HT(3) antagonist, ondansetron, on fasting and postprandial small bowel water content assessed by magnetic resonance imaging.
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pubmed:affiliation |
Nottingham Digestive Diseases Centre, Nottingham University Hospitals NHS Trust, University of Nottingham, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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