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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-1-19
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pubmed:abstractText |
A relationship between primary hyperparathyroidism (pHPT) and pancreatitis has long been debated and remains a rare epiphenomenon. In a cohort of patients with pHPT and pancreatitis mutations in the serine protease inhibitor Kazal type I (SPINK1) and cystic fibrosis transmembrane conductance regulator (CFTR) genes, that increase the risk for pancreatitis have already been detected. Among the identification of additional pancreatitis-associtated mutations in the Chymotrypsin C gene (CTRC) it became clear that also protective genetic variants exist in the anionic trypsinogen gene (PRSS2) that decrease susceptibility for pancreatitis. Our aim was to detect either protective or inducing genetic factors in a large cohort of pHPT patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1439-3646
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pubmed:author |
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pubmed:copyrightInfo |
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York.
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pubmed:issnType |
Electronic
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pubmed:volume |
119
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
26-9
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pubmed:meshHeading |
pubmed-meshheading:20625975-Aged,
pubmed-meshheading:20625975-Chymotrypsin,
pubmed-meshheading:20625975-DNA Mutational Analysis,
pubmed-meshheading:20625975-Databases, Factual,
pubmed-meshheading:20625975-Female,
pubmed-meshheading:20625975-Genetic Association Studies,
pubmed-meshheading:20625975-Genetic Predisposition to Disease,
pubmed-meshheading:20625975-Humans,
pubmed-meshheading:20625975-Hyperparathyroidism, Primary,
pubmed-meshheading:20625975-Male,
pubmed-meshheading:20625975-Middle Aged,
pubmed-meshheading:20625975-Pancreatitis,
pubmed-meshheading:20625975-Polymerase Chain Reaction,
pubmed-meshheading:20625975-Trypsin,
pubmed-meshheading:20625975-Trypsinogen
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pubmed:year |
2011
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pubmed:articleTitle |
Multifactorial genesis of pancreatitis in primary hyperparathyroidism: evidence for "protective" (PRSS2) and "destructive" (CTRC) genetic factors.
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pubmed:affiliation |
Department of Medicine I, St. Josef-Hospital, Ruhr-University, Medical School, Bochum, Germany. peter.felderbauer@rub.de
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pubmed:publicationType |
Journal Article
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