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rdf:type |
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lifeskim:mentions |
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0025914,
umls-concept:C0026336,
umls-concept:C0026809,
umls-concept:C0027651,
umls-concept:C0079427,
umls-concept:C0243125,
umls-concept:C0542341,
umls-concept:C0699900,
umls-concept:C1325410,
umls-concept:C1333573
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pubmed:issue |
7
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pubmed:dateCreated |
2010-7-13
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pubmed:abstractText |
The ubiquitin-proteasome system is the primary proteolysis machine for controlling protein stability of the majority of regulatory proteins including those that are critical for cancer development. The forkhead box transcription factor FOXO3 plays a key role in regulating tumor suppression; however, the control of FOXO3 protein stability remains to be established. It is crucial to elucidate the molecular mechanisms underlying the ubiquitin-mediated degradation of FOXO3 tumor suppressor.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-10102273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-10228155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-10531035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-11607034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-11964479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-12016299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-12114024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-12239572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-12432242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-12621150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-12843402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-14978268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-15021890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-15084260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-15890021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-15917664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-16034054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-16288288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-17038621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-17254960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-17254969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-17254970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-18344987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-18371339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-18391973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-18391976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-18929646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-19196987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-9660940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20625400-9859996
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e11171
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pubmed:meshHeading |
pubmed-meshheading:20625400-Animals,
pubmed-meshheading:20625400-Cell Cycle,
pubmed-meshheading:20625400-Cell Line,
pubmed-meshheading:20625400-Cell Line, Tumor,
pubmed-meshheading:20625400-Fluorescent Antibody Technique,
pubmed-meshheading:20625400-Forkhead Transcription Factors,
pubmed-meshheading:20625400-Humans,
pubmed-meshheading:20625400-Immunoblotting,
pubmed-meshheading:20625400-Immunohistochemistry,
pubmed-meshheading:20625400-Immunoprecipitation,
pubmed-meshheading:20625400-Mice,
pubmed-meshheading:20625400-Mice, Nude,
pubmed-meshheading:20625400-Phosphorylation,
pubmed-meshheading:20625400-RNA, Small Interfering,
pubmed-meshheading:20625400-Ubiquitin,
pubmed-meshheading:20625400-beta-Transducin Repeat-Containing Proteins
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pubmed:year |
2010
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pubmed:articleTitle |
Inhibition of FOXO3 tumor suppressor function by betaTrCP1 through ubiquitin-mediated degradation in a tumor mouse model.
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pubmed:affiliation |
Department of Molecular Pathology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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