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rdf:type |
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lifeskim:mentions |
umls-concept:C0005516,
umls-concept:C0006142,
umls-concept:C0017337,
umls-concept:C0035647,
umls-concept:C0205263,
umls-concept:C0205419,
umls-concept:C0220901,
umls-concept:C0242184,
umls-concept:C0965644,
umls-concept:C1333897,
umls-concept:C1521761,
umls-concept:C1704838
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pubmed:dateCreated |
2010-8-9
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pubmed:abstractText |
Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional regulator of genes regulating oxygen homeostasis. The HIF-1 protein is composed of two HIF-1alpha and HIF-1beta/aryl hydrocarbon receptor nuclear translocator (ARNT) subunits. The prognostic relevance of HIF-1alpha protein overexpression has been shown in breast cancer. The impact of HIF-1alpha alternative splice variant expression on breast cancer prognosis in terms of metastasis risk is not well known.
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pubmed:commentsCorrections |
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20624301-9782081
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1741-7015
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pubmed:author |
pubmed-author:BeaufilsNathalieN,
pubmed-author:BonnierPascalP,
pubmed-author:CharpinColetteC,
pubmed-author:DalesJean-PhilippeJP,
pubmed-author:Formisano-TrézinyChristineC,
pubmed-author:GabertJeanJ,
pubmed-author:GiusianoSophieS,
pubmed-author:PaulyVanessaV,
pubmed-author:PicardChristopheC,
pubmed-author:PradelVincentV,
pubmed-author:SilvyMoniqueM
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
44
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pubmed:dateRevised |
2010-9-30
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pubmed:meshHeading |
pubmed-meshheading:20624301-Adolescent,
pubmed-meshheading:20624301-Adult,
pubmed-meshheading:20624301-Aged,
pubmed-meshheading:20624301-Biological Markers,
pubmed-meshheading:20624301-Breast Neoplasms,
pubmed-meshheading:20624301-Child,
pubmed-meshheading:20624301-Female,
pubmed-meshheading:20624301-Gene Expression Profiling,
pubmed-meshheading:20624301-Humans,
pubmed-meshheading:20624301-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:20624301-Middle Aged,
pubmed-meshheading:20624301-Neoplasm Metastasis,
pubmed-meshheading:20624301-Prognosis,
pubmed-meshheading:20624301-Protein Isoforms,
pubmed-meshheading:20624301-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20624301-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Hypoxia inducible factor 1alpha gene (HIF-1alpha) splice variants: potential prognostic biomarkers in breast cancer.
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