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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2010-9-2
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pubmed:abstractText |
IL-2 and IL-7 share a common gamma-chain receptor and are critical for T-cell homeostasis. We aimed to clarify the reciprocal roles of IL-2 and IL-7 in the development and persistence of chronic colitis. We performed a series of adoptive transfers of IL-2(-/-) CD4(+)CD45RB(high) T cells into RAG-2(-/-) mice and assessed the role of IL-2 in the induction of IL-7R alpha on colitogenic CD4(+) T cells and the development of chronic colitis. RAG-2(-/-) mice transferred with WT but not with IL-2(-/-) CD4(+)CD45RB(high) T cells developed Th1/Th17-mediated colitis. Consistently, re-expression of IL-7R alpha was severely impaired on IL-2(-/-) but not on WT CD4(+) T cells from the transferred mice. To exclude a contribution of the preclinical autoimmunity of IL-2(-/-)mice, WT Ly5.1(+) or IL-2(-/-) Ly5.2(+) CD4(+)CD45RB(high) T cells from GFP mice previously transplanted with the same number of WT and IL-2(-/-) BM cells were transferred into RAG-2(-/-) mice. RAG-2(-/-) mice transferred with IL-2(-/-)-derived CD4(+)CD45RB(high) T cells did not develop colitis, but their splenic CD4(+) T cells changed from effector-memory to central-memory type. These results show that IL-2 is critically involved in the establishment and maintenance of IL-7-dependent colitogenic memory CD4(+)IL-7R alpha(high) T cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-17,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-7,
http://linkedlifedata.com/resource/pubmed/chemical/Rag2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-7,
http://linkedlifedata.com/resource/pubmed/chemical/interleukin-7 receptor, alpha chain
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1521-4141
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pubmed:author |
pubmed-author:HibiToshifumiT,
pubmed-author:KameyamaKaoriK,
pubmed-author:KanaiTakanoriT,
pubmed-author:NakamuraTetsuyaT,
pubmed-author:NemotoYasuhiroY,
pubmed-author:OkamotoRyuichiR,
pubmed-author:SakamotoNaoyaN,
pubmed-author:ShinoharaTamakoT,
pubmed-author:TotsukaTerujiT,
pubmed-author:TsuchiyaKiichiroK,
pubmed-author:WatanabeMamoruM
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pubmed:issnType |
Electronic
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2423-36
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pubmed:meshHeading |
pubmed-meshheading:20623548-Adoptive Transfer,
pubmed-meshheading:20623548-Animals,
pubmed-meshheading:20623548-Antigens, CD4,
pubmed-meshheading:20623548-Bone Marrow Transplantation,
pubmed-meshheading:20623548-Chronic Disease,
pubmed-meshheading:20623548-Colitis,
pubmed-meshheading:20623548-DNA-Binding Proteins,
pubmed-meshheading:20623548-Immunologic Memory,
pubmed-meshheading:20623548-Interleukin-17,
pubmed-meshheading:20623548-Interleukin-2,
pubmed-meshheading:20623548-Interleukin-7,
pubmed-meshheading:20623548-Mice,
pubmed-meshheading:20623548-Mice, Inbred C57BL,
pubmed-meshheading:20623548-Mice, Knockout,
pubmed-meshheading:20623548-Receptors, Interleukin-7,
pubmed-meshheading:20623548-T-Lymphocyte Subsets,
pubmed-meshheading:20623548-Th1 Cells,
pubmed-meshheading:20623548-Transplantation Chimera
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pubmed:year |
2010
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pubmed:articleTitle |
IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells in chronic colitis.
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pubmed:affiliation |
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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