Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1991-8-8
|
| pubmed:abstractText |
Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS) is characterized by microangiopathic hemolytic anemia, thrombocytopenia, fever, central nervous system abnormalities, and renal dysfunction. In early reports the mortality approached 100 percent. A treatment protocol was introduced in 1979 for patients admitted to Johns Hopkins Hospital with the diagnosis of TTP-HUS. Treatment regimens included 200 mg of prednisone a day, for patients with minimal symptoms and no central nervous system symptoms, and prednisone plus plasma exchange, for patients with rapid clinical deterioration who did not improve after 48 hours of prednisone alone and for patients presenting with central nervous system symptoms and rapidly declining hematocrit values and platelet counts.
|
| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0028-4793
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
8
|
| pubmed:volume |
325
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
398-403
|
| pubmed:dateRevised |
2010-3-24
|
| pubmed:meshHeading |
pubmed-meshheading:2062331-Adolescent,
pubmed-meshheading:2062331-Adult,
pubmed-meshheading:2062331-Aged,
pubmed-meshheading:2062331-Aspirin,
pubmed-meshheading:2062331-Blood Transfusion,
pubmed-meshheading:2062331-Dipyridamole,
pubmed-meshheading:2062331-Female,
pubmed-meshheading:2062331-Hemolytic-Uremic Syndrome,
pubmed-meshheading:2062331-Humans,
pubmed-meshheading:2062331-Male,
pubmed-meshheading:2062331-Middle Aged,
pubmed-meshheading:2062331-Monitoring, Physiologic,
pubmed-meshheading:2062331-Plasma,
pubmed-meshheading:2062331-Plasma Exchange,
pubmed-meshheading:2062331-Prednisone,
pubmed-meshheading:2062331-Pregnancy,
pubmed-meshheading:2062331-Pregnancy Complications, Hematologic,
pubmed-meshheading:2062331-Purpura, Thrombotic Thrombocytopenic,
pubmed-meshheading:2062331-Research Design,
pubmed-meshheading:2062331-Splenectomy
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Improved survival in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Clinical experience in 108 patients.
|
| pubmed:affiliation |
Department of Medicine, Johns Hopkins University School of Medicine and Hospital, Baltimore, MD 21205.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|