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rdf:type |
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lifeskim:mentions |
umls-concept:C0030705,
umls-concept:C0087111,
umls-concept:C0205466,
umls-concept:C0439831,
umls-concept:C0871261,
umls-concept:C1148363,
umls-concept:C1425475,
umls-concept:C1533728,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1882417,
umls-concept:C2911692
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pubmed:issue |
3
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pubmed:dateCreated |
2010-8-30
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pubmed:abstractText |
Polymorphisms in the region of the interleukin (IL)-28B gene on chromosome 19 have been associated with peginterferon-alfa-induced clearance of genotype 1 hepatitis C virus (HCV); there are no data for patients with genotype 2 or 3 HCV. We evaluated the effects of IL-28B polymorphisms on response to treatment with peginterferon and ribavirin in a well-characterized cohort of genotype 2/3 patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/IL28B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukins,
http://linkedlifedata.com/resource/pubmed/chemical/Polyethylene Glycols,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ribavirin,
http://linkedlifedata.com/resource/pubmed/chemical/interferon alfa-2b,
http://linkedlifedata.com/resource/pubmed/chemical/peginterferon alfa-2b
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1528-0012
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pubmed:author |
pubmed-author:BaccaDonatoD,
pubmed-author:CarrettaVitoV,
pubmed-author:GoldsteinDavid BDB,
pubmed-author:MangiaAlessandraA,
pubmed-author:McHutchisonJohn GJG,
pubmed-author:MinervaNicolaN,
pubmed-author:MottolaLeonardoL,
pubmed-author:PatelKeyurK,
pubmed-author:PetruzzellisDanielaD,
pubmed-author:PiazzollaValeriaV,
pubmed-author:SantoroRosannaR,
pubmed-author:ShiannaKevin VKV,
pubmed-author:ThompsonAlexander JAJ,
pubmed-author:TillmannHans LHL
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pubmed:copyrightInfo |
Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
139
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
821-7, 827.e1
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20621700-Adult,
pubmed-meshheading:20621700-Antiviral Agents,
pubmed-meshheading:20621700-Chi-Square Distribution,
pubmed-meshheading:20621700-Drug Therapy, Combination,
pubmed-meshheading:20621700-Female,
pubmed-meshheading:20621700-Gene Frequency,
pubmed-meshheading:20621700-Genotype,
pubmed-meshheading:20621700-Hepacivirus,
pubmed-meshheading:20621700-Hepatitis C,
pubmed-meshheading:20621700-Humans,
pubmed-meshheading:20621700-Interferon-alpha,
pubmed-meshheading:20621700-Interleukins,
pubmed-meshheading:20621700-Italy,
pubmed-meshheading:20621700-Logistic Models,
pubmed-meshheading:20621700-Male,
pubmed-meshheading:20621700-Odds Ratio,
pubmed-meshheading:20621700-Polyethylene Glycols,
pubmed-meshheading:20621700-Polymorphism, Genetic,
pubmed-meshheading:20621700-Prospective Studies,
pubmed-meshheading:20621700-RNA, Viral,
pubmed-meshheading:20621700-Recombinant Proteins,
pubmed-meshheading:20621700-Recurrence,
pubmed-meshheading:20621700-Ribavirin,
pubmed-meshheading:20621700-Risk Assessment,
pubmed-meshheading:20621700-Risk Factors,
pubmed-meshheading:20621700-Time Factors,
pubmed-meshheading:20621700-Treatment Outcome,
pubmed-meshheading:20621700-Viral Load
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pubmed:year |
2010
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pubmed:articleTitle |
An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response.
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pubmed:affiliation |
Liver Unit, Instituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy. a.mangia@tin.it
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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