Source:http://linkedlifedata.com/resource/pubmed/id/20621586
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2010-9-6
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| pubmed:abstractText |
The release profile of a novel oral ileocolonic drug delivery technology (ColoPulse-technology) was assessed by a combination of conventional kinetics of a marker substance in blood and site-specific signaling by stable isotope technology. Since ileocolonic delivery involves the drug release in a region in which bacteria are highly present, a prolonged lag time should coincide with proven bacterial enzyme activity. The latter can be tested using 13C-urea as the marker substance. The study was designed as a two period (uncoated versus coated capsule) crossover single dose bioavailability study in healthy subjects. The 13C-recovery data after oral administration of 13C-urea using the ColoPulse delivery system showed a delayed sigmoid release in all subjects with a lag time of > 3h (median: 330 min). Release was achieved in a urease-containing intestinal segment in all healthy subjects. Complete release in the ileocolonic region was achieved in 10 of 11 subjects. The ColoPulse-technology therefore enables specific and reliable drug delivery in the ileocolonic region in healthy volunteers.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
1873-4995
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| pubmed:author | |
| pubmed:copyrightInfo |
2010 Elsevier B.V. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:day |
15
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| pubmed:volume |
146
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
334-40
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| pubmed:meshHeading |
pubmed-meshheading:20621586-Administration, Oral,
pubmed-meshheading:20621586-Adult,
pubmed-meshheading:20621586-Biological Availability,
pubmed-meshheading:20621586-Colon,
pubmed-meshheading:20621586-Drug Delivery Systems,
pubmed-meshheading:20621586-Female,
pubmed-meshheading:20621586-Humans,
pubmed-meshheading:20621586-Ileum,
pubmed-meshheading:20621586-Kinetics,
pubmed-meshheading:20621586-Male,
pubmed-meshheading:20621586-Models, Biological,
pubmed-meshheading:20621586-Urea
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| pubmed:year |
2010
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| pubmed:articleTitle |
Oral ileocolonic drug delivery by the colopulse-system: a bioavailability study in healthy volunteers.
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| pubmed:affiliation |
Department of Hospital and Clinical Pharmacy, University Medical Center Groningen, University of Groningen, The Netherlands. reinout.schellekens@kpnplanet.nl
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| pubmed:publicationType |
Journal Article
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