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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2010-7-27
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pubmed:abstractText |
The search for small molecules that preferentially target the functionally important surfaces of estrogen receptor and disrupt the transcriptional activity in the cell has emerged as a promising area towards rationale based drug design. Herein, we report substituted styryl chromones as a new class of compounds that exhibit selectivity for ERbeta binding at the second binding site of HT and antiproliferative activity in human breast cancer cell line.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:copyrightInfo |
2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4945-50
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pubmed:meshHeading |
pubmed-meshheading:20621472-Antineoplastic Agents,
pubmed-meshheading:20621472-Benzopyrans,
pubmed-meshheading:20621472-Binding Sites,
pubmed-meshheading:20621472-Breast Neoplasms,
pubmed-meshheading:20621472-Cell Line, Tumor,
pubmed-meshheading:20621472-Chromones,
pubmed-meshheading:20621472-Computer Simulation,
pubmed-meshheading:20621472-Drug Design,
pubmed-meshheading:20621472-Estrogen Receptor beta,
pubmed-meshheading:20621472-Female,
pubmed-meshheading:20621472-Humans,
pubmed-meshheading:20621472-Styrenes,
pubmed-meshheading:20621472-Thermodynamics
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pubmed:year |
2010
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pubmed:articleTitle |
Synthesis and docking studies on styryl chromones exhibiting cytotoxicity in human breast cancer cell line.
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pubmed:affiliation |
Chemical Synthesis Group, Amity Institute of Biotechnology, Amity University Sector 125, Noida, India. sbhatnagar@aib.amity.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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