Linked Life Data

20621020

Source:http://linkedlifedata.com/resource/pubmed/id/20621020

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-7-12
pubmed:abstractText
Thyroid peroxidase (TPO) is the key enzyme involved in thyroid hormone synthesis. Several mutations in the TPO gene may affect the normal growth and development of mammals. In this study, the TPO gene was mapped, its expression level was determined in thyroid grand at the age of 1, 20, 45, 60, 90, 120 and 150 days for Jinhua pig, the alternative splicing form was searched and the single nucleotide polymorphism (SNP, A/G(642)) of TPO gene was analyzed. The results showed that the porcine TPO was mapped to 3q22-27, the expression level of TPO was relatively stable among the various ages and two novel transcript variants in porcine TPO gene were found: the splicing variant TPO-2 lacked exon 8, while TPO-3 lacked exon 8 and exon 14, 15, 16. Moreover, we found that the SNP of A/G(642) in the fourteenth exon of TPO gene was significantly associated with ham weight (P < 0.05). Our results provided important basis on the regulation and metabolism of the thyroid gland in animals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1673-8527
pubmed:author
pubmed:copyrightInfo
Copyright 2010 Institute of Genetics and Developmental Biology and the Genetics Society of China. Published by Elsevier Ltd. All rights reserved.
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
381-8
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Molecular characterization of thyroid peroxidase gene in porcine (Sus scrofa).
pubmed:affiliation
College of Animal Sciences, Zhejiang University, Hangzhou, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't