Linked Life Data

20620971

Source:http://linkedlifedata.com/resource/pubmed/id/20620971

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-7-12
pubmed:abstractText
Monoclonal B-lymphocytosis (MBL) is defined as the presence of a population of monoclonal B-cells, usually with a chronic lymphocytic leukaemia (CLL) phenotype, which comprise fewer than 5000 cells per microl with no evidence of tissue involvement. Over the past few years, MBL has been clearly defined and differentiated from CLL so that individuals with MBL are no longer inappropriately labelled as suffering from leukaemia. In this review, we will describe the entity of MBL and summarise the evidence that underlies the current theory on the pathophysiology of the disorder, the relationship with CLL and the probability of developing progressive disease requiring treatment. In addition, we will evaluate the importance of further clinical investigations, in particular, the relevance of screening for MBL and undertaking bone marrow investigations according to the clinical setting and B-cell phenotype.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1532-1924
pubmed:author
pubmed:copyrightInfo
Copyright 2010. Published by Elsevier Ltd.
pubmed:issnType
Electronic
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
61-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Clinical and diagnostic implications of monoclonal B-cell lymphocytosis.
pubmed:affiliation
Haematological Malignancy Diagnostic Service, St. James's Institute of Oncology, Bexley Wing, Beckett Street, Leeds LS9 7TF, UK.
pubmed:publicationType
Journal Article, Review