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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-7-12
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pubmed:abstractText |
Tumor progression shares many characteristics with the process of epithelial-to-mesenchymal transition (EMT). Cells that have undergone an EMT are known to have an increased resistance to apoptosis. CD95/Fas is an apoptosis-inducing receptor expressed on many tissues and tumor cells. During tumor progression CD95 is frequently downregulated, and tumor cells lose apoptosis sensitivity. miR-200 microRNAs repress both the EMT-inducing ZEB1 and ZEB2 transcription factors. We now demonstrate that miR-200c sensitizes cells to apoptosis mediated by CD95. We have identified the apoptosis inhibitor FAP-1 as a target for miR-200c. FAP-1 was demonstrated to be responsible for the reduced sensitivity to CD95-mediated apoptosis in cells with inhibited miR-200. The identification of FAP-1 as an miR-200c target provides a molecular mechanism to explain both the downregulation of CD95 expression and the reduction in sensitivity of cells to CD95-mediated apoptosis that is observed in the context of reduced miR-200 expression during tumor progression.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-10398166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-10537175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-10647931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-10918185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-11106428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-11172597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-11274632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-11290551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-11598958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-11683408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-12655293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-12724420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-14504390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-15907590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-16187021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-16306044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-16498403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-16888780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-17482535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-17585049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-17804704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-17982484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-18160445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-18376396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-18381893,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-18836476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-19167326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-19221491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-7536343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20620960-9079683
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1097-4164
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
25
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
908-15
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pubmed:dateRevised |
2011-8-1
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pubmed:meshHeading |
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pubmed:year |
2010
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pubmed:articleTitle |
miR-200c regulates induction of apoptosis through CD95 by targeting FAP-1.
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pubmed:affiliation |
The Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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