| pubmed-article:20620943 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20620943 | lifeskim:mentions | umls-concept:C0205102 | lld:lifeskim |
| pubmed-article:20620943 | lifeskim:mentions | umls-concept:C0034789 | lld:lifeskim |
| pubmed-article:20620943 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:20620943 | lifeskim:mentions | umls-concept:C0020855 | lld:lifeskim |
| pubmed-article:20620943 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:20620943 | lifeskim:mentions | umls-concept:C1704686 | lld:lifeskim |
| pubmed-article:20620943 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:20620943 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:20620943 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:20620943 | pubmed:dateCreated | 2010-7-12 | lld:pubmed |
| pubmed-article:20620943 | pubmed:abstractText | Memory B cells express high-affinity, immunoglobulin GB cell receptors (IgG BCRs) that enhance B cell responses, giving rise to the rapid production of high-affinity, IgG antibodies. Despite the central role of IgG BCRs in memory responses, the mechanisms by which the IgG BCRs function to enhance B cell responses are not fully understood. Using high-resolution live-cell imaging, we showed that IgG1 BCRs dramatically enhanced the earliest BCR-intrinsic events that followed within seconds of B cells' encounter with membrane bound antigen, including BCR oligomerization and BCR microcluster growth, leading to Syk kinase recruitment and calcium responses. The enhancement of these early events was dependent on a membrane proximal region of the IgG1 cytoplasmic tail not previously appreciated to play a role in IgG1 BCR signaling. Thus, intrinsic properties of the IgG1 BCR enhance early antigen-driven events that ultimately translate into heightened signaling. | lld:pubmed |
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| pubmed-article:20620943 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20620943 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20620943 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20620943 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20620943 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20620943 | pubmed:issn | 1097-4180 | lld:pubmed |
| pubmed-article:20620943 | pubmed:author | pubmed-author:PierceSusan... | lld:pubmed |
| pubmed-article:20620943 | pubmed:author | pubmed-author:LiuWanliW | lld:pubmed |
| pubmed-article:20620943 | pubmed:author | pubmed-author:MeckelTobiasT | lld:pubmed |
| pubmed-article:20620943 | pubmed:author | pubmed-author:SohnHae WonHW | lld:pubmed |
| pubmed-article:20620943 | pubmed:author | pubmed-author:TolarPavelP | lld:pubmed |
| pubmed-article:20620943 | pubmed:copyrightInfo | Copyright 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20620943 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20620943 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:20620943 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:20620943 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20620943 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20620943 | pubmed:pagination | 778-89 | lld:pubmed |
| pubmed-article:20620943 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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| pubmed-article:20620943 | pubmed:meshHeading | pubmed-meshheading:20620943... | lld:pubmed |
| pubmed-article:20620943 | pubmed:meshHeading | pubmed-meshheading:20620943... | lld:pubmed |
| pubmed-article:20620943 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20620943 | pubmed:articleTitle | Intrinsic properties of immunoglobulin IgG1 isotype-switched B cell receptors promote microclustering and the initiation of signaling. | lld:pubmed |
| pubmed-article:20620943 | pubmed:affiliation | Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA. | lld:pubmed |
| pubmed-article:20620943 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20620943 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
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