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pubmed-article:20620398pubmed:abstractTextBladder urothelial cell carcinoma is uncommon in young patients. We recently reported a series of tumors in patients younger than 20 years at diagnosis and performed exhaustive genetic screening for molecular alterations. Few events typical of bladder urothelial cell carcinoma were detected. Since many carcinogenic events occur at the epigenetic rather than the genetic level, we analyzed the same tumors for alterations in DNA hypermethylation. We compared our findings with those in tumors in older patients with similar pathological profiles.lld:pubmed
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pubmed-article:20620398pubmed:authorpubmed-author:OwenHelen CHClld:pubmed
pubmed-article:20620398pubmed:copyrightInfoCopyright (c) 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.lld:pubmed
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pubmed-article:20620398pubmed:volume184lld:pubmed
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pubmed-article:20620398pubmed:pagination459-63lld:pubmed
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pubmed-article:20620398pubmed:articleTitleLow frequency of epigenetic events in urothelial tumors in young patients.lld:pubmed
pubmed-article:20620398pubmed:affiliationAcademic Urology Unit and Institute for Cancer Studies, University of Sheffield, Sheffield, United Kingdom.lld:pubmed
pubmed-article:20620398pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20620398pubmed:publicationTypeComparative Studylld:pubmed