|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2010-7-12
|
|
pubmed:abstractText |
Bladder urothelial cell carcinoma is uncommon in young patients. We recently reported a series of tumors in patients younger than 20 years at diagnosis and performed exhaustive genetic screening for molecular alterations. Few events typical of bladder urothelial cell carcinoma were detected. Since many carcinogenic events occur at the epigenetic rather than the genetic level, we analyzed the same tumors for alterations in DNA hypermethylation. We compared our findings with those in tumors in older patients with similar pathological profiles.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1527-3792
|
|
pubmed:author |
pubmed-author:AminMahul BMB,
pubmed-author:BlaszykHH,
pubmed-author:CattoJames WJW,
pubmed-author:DehnerLouis PLP,
pubmed-author:EpsteinJohnathan IJI,
pubmed-author:FineSamson WSW,
pubmed-author:GiedlJJ,
pubmed-author:HartmannArndtA,
pubmed-author:HughesDavidD,
pubmed-author:HumphreyPeter APA,
pubmed-author:OwenHelen CHC,
pubmed-author:StoehrRobertR,
pubmed-author:WildPeter JPJ
|
|
pubmed:copyrightInfo |
Copyright (c) 2010 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
184
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
459-63
|
|
pubmed:meshHeading |
pubmed-meshheading:20620398-Adolescent,
pubmed-meshheading:20620398-Adult,
pubmed-meshheading:20620398-Age Factors,
pubmed-meshheading:20620398-Aged,
pubmed-meshheading:20620398-Carcinoma, Transitional Cell,
pubmed-meshheading:20620398-Epigenesis, Genetic,
pubmed-meshheading:20620398-Female,
pubmed-meshheading:20620398-Humans,
pubmed-meshheading:20620398-Male,
pubmed-meshheading:20620398-Middle Aged,
pubmed-meshheading:20620398-Urinary Bladder Neoplasms,
pubmed-meshheading:20620398-Young Adult
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Low frequency of epigenetic events in urothelial tumors in young patients.
|
|
pubmed:affiliation |
Academic Urology Unit and Institute for Cancer Studies, University of Sheffield, Sheffield, United Kingdom.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
