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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2010-7-27
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pubmed:abstractText |
A series of aminomethylpyrazoles were prepared and evaluated using cell-based Smoothened beta-lactamase reporter assay and Smoothened binding assay. Potent Smoothened antagonists 10k and 10l were found to inhibit hair growth in vivo in the C3H/HeN mouse hair growth model. The more selective compound 10l was tested negative in the 3T3 NRU assay, indicating a low risk for causing photo-irritation and was efficacious using the C3H/HeN mouse hair growth model although it was slightly less efficacious than that of the reference compound eflornithine (7).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:ConradiRobertR,
pubmed-author:DettlingDanielleD,
pubmed-author:FitzgeraldLaura RLR,
pubmed-author:FleischerLaura LLL,
pubmed-author:HarterWilliam GWG,
pubmed-author:JiChristy XiaodongCX,
pubmed-author:LiJie JackJJ,
pubmed-author:NgomN NNN,
pubmed-author:OsakBellaB,
pubmed-author:ReddySatyaS,
pubmed-author:ShanmugasundaramVeerabahuV,
pubmed-author:SmithYvonneY,
pubmed-author:SwaroopManjuM,
pubmed-author:WangZenquanZ,
pubmed-author:YueWen-SongWS
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pubmed:copyrightInfo |
2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4932-5
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pubmed:meshHeading |
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pubmed:year |
2010
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pubmed:articleTitle |
Smoothened antagonists for hair inhibition.
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pubmed:affiliation |
Department of Chemistry, Michigan Laboratories, Pfizer Global Research & Development, 2800 Plymouth Rd., Ann Arbor, MI 48105, USA. jack.li@bms.com
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pubmed:publicationType |
Journal Article
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