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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-2-22
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pubmed:abstractText |
Glucocorticoids are the sole drugs clinically used in Duchenne muscular dystrophy, in spite of the relevant side effects. Combination of glucocorticoids with synergistic drugs may be one strategy to lower doses and control side effects, meanwhile providing wider control of the complex pathology. This study is a preclinical evaluation of the effect of a combined treatment of ?-methyl-prednisolone (PDN) with taurine, a safe aminoacid with positive effects on some pathology-related events.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1365-2990
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pubmed:author |
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pubmed:copyrightInfo |
© 2011 The Authors. Neuropathology and Applied Neurobiology © 2011 British Neuropathological Society.
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pubmed:issnType |
Electronic
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
243-56
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pubmed:meshHeading |
pubmed-meshheading:20618838-Animals,
pubmed-meshheading:20618838-Chromatography, High Pressure Liquid,
pubmed-meshheading:20618838-Creatine Kinase,
pubmed-meshheading:20618838-Disease Models, Animal,
pubmed-meshheading:20618838-Drug Synergism,
pubmed-meshheading:20618838-Drug Therapy, Combination,
pubmed-meshheading:20618838-Glucocorticoids,
pubmed-meshheading:20618838-L-Lactate Dehydrogenase,
pubmed-meshheading:20618838-Male,
pubmed-meshheading:20618838-Methylprednisolone,
pubmed-meshheading:20618838-Mice,
pubmed-meshheading:20618838-Mice, Inbred C57BL,
pubmed-meshheading:20618838-Mice, Inbred mdx,
pubmed-meshheading:20618838-Muscle, Skeletal,
pubmed-meshheading:20618838-Muscle Strength,
pubmed-meshheading:20618838-Muscular Dystrophy, Animal,
pubmed-meshheading:20618838-Muscular Dystrophy, Duchenne,
pubmed-meshheading:20618838-Patch-Clamp Techniques,
pubmed-meshheading:20618838-Taurine
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pubmed:year |
2011
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pubmed:articleTitle |
Evaluation of potential synergistic action of a combined treatment with alpha-methyl-prednisolone and taurine on the mdx mouse model of Duchenne muscular dystrophy.
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pubmed:affiliation |
Unit of Pharmacology, Department of Pharmaco-biology, Faculty of Pharmacy Department of Human Anatomy and Histology, Faculty of Medicine, University of Bari Metabolic Disease Unit, Paediatric Hospital Giovanni XXIII, Bari, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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