Linked Life Data

20616540

Source:http://linkedlifedata.com/resource/pubmed/id/20616540

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SubjectPredicateObjectContext
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pubmed-article:20616540pubmed:dateCreated2010-7-28lld:pubmed
pubmed-article:20616540pubmed:abstractTextHypercalcemia in malignancies is a frequent complication, mostly affecting patients with solid tumors or multiple myeloma. Calcium elevation is induced by direct bone infiltration of a tumor mass or through calcium liberation from the skeleton by a humoral mediator. The latter mechanism is referred to as humoral hypercalcemia of malignancy (HHM). Frequent mediators of HHM are parathyroid hormone-related peptides (PTHrP). We report a patient with chronic lymphocytic leukemia and hypercalcemia induced by PTHrP. In contrast to solid tumors and myeloma, PTHrP-induced HHM is very rare in low-grad lymphoma including chronic lymphocytic leukemia. Therapeutical approaches consist of cytoreductive treatment and calcium-lowering therapy with bisphosphonates.lld:pubmed
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pubmed-article:20616540pubmed:authorpubmed-author:MassenkeilGGlld:pubmed
pubmed-article:20616540pubmed:authorpubmed-author:SchmiegelWWlld:pubmed
pubmed-article:20616540pubmed:authorpubmed-author:TeschendorfCClld:pubmed
pubmed-article:20616540pubmed:authorpubmed-author:BaraniskinAAlld:pubmed
pubmed-article:20616540pubmed:authorpubmed-author:KampfenkelTob...lld:pubmed
pubmed-article:20616540pubmed:copyrightInfoCopyright 2010 S. Karger AG, Basel.lld:pubmed
pubmed-article:20616540pubmed:issnTypeElectroniclld:pubmed
pubmed-article:20616540pubmed:volume124lld:pubmed
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pubmed-article:20616540pubmed:pagination57-60lld:pubmed
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pubmed-article:20616540pubmed:year2010lld:pubmed
pubmed-article:20616540pubmed:articleTitleA rare case of chronic lymphocytic leukemia with hypercalcemia induced by elevated parathyroid hormone-related peptides.lld:pubmed
pubmed-article:20616540pubmed:affiliationDepartment of Internal Medicine, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany. tobias.kampfenkel@rub.delld:pubmed
pubmed-article:20616540pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20616540pubmed:publicationTypeCase Reportslld:pubmed