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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
28
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pubmed:dateCreated |
2010-7-14
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pubmed:databankReference |
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pubmed:abstractText |
Preexisting T-cell immunity directed at conserved viral regions promotes enhanced recovery from influenza virus infections, with there being some evidence of cross-protection directed at variable peptides. Strikingly, many of the immunogenic peptides derived from the current pandemic A(H1N1)-2009 influenza virus are representative of the catastrophic 1918 "Spanish flu" rather than more recent "seasonal" strains. We present immunological and structural analyses of cross-reactive CD8(+) T-cell-mediated immunity directed at a variable (although highly cross-reactive) immunodominant NP(418-426) peptide that binds to a large B7 family (HLA-B*3501/03/0702) found throughout human populations. Memory CD8(+) T-cell specificity was probed for 12 different NP(418) mutants that emerged over the 9 decades between the 1918 and 2009 pandemics. Although there is evidence of substantial cross-reactivity among seasonal NP(418) mutants, current memory T-cell profiles show no preexisting immunity to the 2009-NP(418) variant or the 1918-NP(418) variant. Natural infection with the A(H1N1)-2009 virus, however, elicits CD8(+) T cells specific for the 2009-NP(418) and 1918-NP(418) epitopes. This analysis points to the potential importance of cross-reactive T-cell populations that cover the possible spectrum of T-cell variants and suggests that the identification of key residues/motifs that elicit cross-reactive T-cell sets could facilitate the evolution of immunization protocols that provide a measure of protection against unpredicted pandemic influenza viruses. Thus, it is worth exploring the potential of vaccines that incorporate peptide variants with a proven potential for broader immunogenicity, especially to those that are not recognized by the current memory T-cell pool generated by exposure to influenza variants that cause successive seasonal epidemics.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-11090168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-11567148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-11836437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-12454477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-12954978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-14764717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-15299374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-15494511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-15572765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-16323131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-17082594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-17109469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-17326762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-18270323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-18353950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-18802496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-18842709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-19541958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-19553306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-19840674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-19907052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-19918065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-20007533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-20078408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20616031-20339031
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1091-6490
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pubmed:author |
pubmed-author:DenholmJustin TJT,
pubmed-author:DohertyPeter CPC,
pubmed-author:GrasStephanieS,
pubmed-author:KedzierskaKatherineK,
pubmed-author:KedzierskiLukaszL,
pubmed-author:KelsoAnneA,
pubmed-author:LaurieKarenK,
pubmed-author:LiuYu ChihYC,
pubmed-author:RichardsMichael JMJ,
pubmed-author:RimmelzwaanGuus FGF,
pubmed-author:RossjohnJamieJ,
pubmed-author:TurnerStephen JSJ,
pubmed-author:ValkenburgSophie ASA
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pubmed:issnType |
Electronic
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pubmed:day |
13
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
12599-604
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pubmed:dateRevised |
2011-7-20
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pubmed:meshHeading |
pubmed-meshheading:20616031-CD8-Positive T-Lymphocytes,
pubmed-meshheading:20616031-Cross Protection,
pubmed-meshheading:20616031-Cross Reactions,
pubmed-meshheading:20616031-Disease Outbreaks,
pubmed-meshheading:20616031-Epitopes,
pubmed-meshheading:20616031-HLA-B Antigens,
pubmed-meshheading:20616031-Humans,
pubmed-meshheading:20616031-Immunity, Cellular,
pubmed-meshheading:20616031-Influenza, Human,
pubmed-meshheading:20616031-Influenza A Virus, H1N1 Subtype,
pubmed-meshheading:20616031-Influenza A virus,
pubmed-meshheading:20616031-Influenza Vaccines,
pubmed-meshheading:20616031-Lymphocyte Count,
pubmed-meshheading:20616031-T-Cell Antigen Receptor Specificity,
pubmed-meshheading:20616031-T-Lymphocytes,
pubmed-meshheading:20616031-Viruses
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pubmed:year |
2010
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pubmed:articleTitle |
Cross-reactive CD8+ T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses.
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pubmed:affiliation |
Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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