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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2010-8-3
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pubmed:abstractText |
Maternal thyroid hormones (THs), especially thyroxine (T(4)), are crucial to early brain development in the mammalian embryo. Epidemiological studies and case reports have shown that maternal subclinical hypothyroidism may result in significant negative effects on pregnancy and neurodevelopment of the fetus. To understand the mechanism responsible for these neurological alterations, we induced maternal subclinical hypothyroidism in pregnant rats. Behavior and several genes that are under the control of THs were evaluated in the offspring of TH-deficient rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1557-9077
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
909-15
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pubmed:meshHeading |
pubmed-meshheading:20615128-Animals,
pubmed-meshheading:20615128-Brain,
pubmed-meshheading:20615128-Disease Models, Animal,
pubmed-meshheading:20615128-Female,
pubmed-meshheading:20615128-Hippocampus,
pubmed-meshheading:20615128-Hypothyroidism,
pubmed-meshheading:20615128-Maze Learning,
pubmed-meshheading:20615128-Pregnancy,
pubmed-meshheading:20615128-Pregnancy, Animal,
pubmed-meshheading:20615128-Pregnancy Complications,
pubmed-meshheading:20615128-Prenatal Exposure Delayed Effects,
pubmed-meshheading:20615128-Rats,
pubmed-meshheading:20615128-Rats, Wistar,
pubmed-meshheading:20615128-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20615128-Thyroid Hormones,
pubmed-meshheading:20615128-Thyroxine
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pubmed:year |
2010
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pubmed:articleTitle |
The effect of maternal subclinical hypothyroidism during pregnancy on brain development in rat offspring.
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pubmed:affiliation |
The Institute of Endocrinology, The First Affiliated Hospital, China Medical University , Shenyang, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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