Linked Life Data

20615083

Source:http://linkedlifedata.com/resource/pubmed/id/20615083

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2010-9-2
pubmed:abstractText
Recent studies have shown that angiogenesis plays an important role in the biology of hematological malignancies including essential thrombocythemia (ET). Using cytofluorimetric analysis, the levels of angiogenic factors, as well as the number of circulating endothelial cells (CECs), were determined in 65 patients with ET, including 33 previously untreated and 32 receiving cytoreductive therapy. Correlations between markers of angiogenesis and JAK2-V617F mutational status were also assessed. We found significantly higher levels of vascular endothelial growth factor (VEGF) and markedly decreased levels of placental growth factor in untreated patients with ET with respect to control subjects. VEGF levels were significantly increased in patients with white blood count >8.7 (x 10(9)/L) vs. <8.7 (x 10(9)/L). Furthermore, the levels of VEGF in patients on hydroxyurea (HU) therapy were markedly lower than in untreated patients. It was also demonstrated that the number of all CEC subpopulations (resting, activated, apoptotic, and circulating precursor endothelial cells) was increased in patients with ET in relation to controls, regardless of the JAK2-V617F status, and was not affected by cytoreductive treatment. In conclusion, our study highlights the possible role of angiogenesis in the pathophysiology of ET. It provides evidence that the number of CECs is elevated independently of JAK2-V617F status and is not down-regulated by HU or anagrelide therapy. Our data suggest that VEGF levels are particularly elevated in patients with high leukocytosis. Further investigation should be undertaken to determine the possible role of antiangiogenic therapy in ET.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1029-2403
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1727-33
pubmed:meshHeading
pubmed-meshheading:20615083-Adult, pubmed-meshheading:20615083-Aged, pubmed-meshheading:20615083-Aged, 80 and over, pubmed-meshheading:20615083-Angiogenic Proteins, pubmed-meshheading:20615083-Antineoplastic Agents, pubmed-meshheading:20615083-Apoptosis, pubmed-meshheading:20615083-Case-Control Studies, pubmed-meshheading:20615083-Endothelial Cells, pubmed-meshheading:20615083-Female, pubmed-meshheading:20615083-Flow Cytometry, pubmed-meshheading:20615083-Humans, pubmed-meshheading:20615083-Hydroxyurea, pubmed-meshheading:20615083-Janus Kinase 2, pubmed-meshheading:20615083-Male, pubmed-meshheading:20615083-Middle Aged, pubmed-meshheading:20615083-Mutation, pubmed-meshheading:20615083-Neovascularization, Pathologic, pubmed-meshheading:20615083-Polymerase Chain Reaction, pubmed-meshheading:20615083-Polymorphism, Restriction Fragment Length, pubmed-meshheading:20615083-Pregnancy Proteins, pubmed-meshheading:20615083-Thrombocythemia, Essential, pubmed-meshheading:20615083-Vascular Endothelial Growth Factor A
pubmed:year
2010
pubmed:articleTitle
Plasma levels of angiogenic factors and circulating endothelial cells in essential thrombocythemia: correlation with cytoreductive therapy and JAK2-V617F mutational status.
pubmed:affiliation
Department of Hematology, Medical University of ?ód?, Copernicus Memorial Hospital, ?ód?, Poland. jtrel2001@yahoo.com
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't