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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2010-8-19
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pubmed:abstractText |
The massive depletion of gastrointestinal-tract CD4 T cells is a hallmark of the acute phase of HIV infection. In contrast, the depletion of the lower-respiratory-tract mucosal CD4 T cells as measured in bronchoalveolar lavage (BAL) fluid is more moderate and similar to the depletion of CD4 T cells observed in peripheral blood (PB). To understand better the dynamics of disease pathogenesis and the potential for the reconstitution of CD4 T cells in the lung and PB following the administration of effective antiretroviral therapy, we studied cell-associated viral loads, CD4 T-cell frequencies, and phenotypic and functional profiles of antigen-specific CD4 T cells from BAL fluid and blood before and after the initiation of highly active antiretroviral therapy (HAART). The major findings to emerge were the following: (i) BAL CD4 T cells are not massively depleted or preferentially infected by HIV compared to levels for PB; (ii) BAL CD4 T cells reconstitute after the initiation of HAART, and their infection frequencies decrease; (iii) BAL CD4 T-cell reconstitution appears to occur via the local proliferation of resident BAL CD4 T cells rather than redistribution; and (iv) BAL CD4 T cells are more polyfunctional than CD4 T cells in blood, and their functional profile is relatively unchanged after the initiation of HAART. Taken together, these data suggest mechanisms for mucosal CD4 T-cell depletion and interventions that might aid in the reconstitution of mucosal CD4 T cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20610726-10228108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20610726-10229228,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20610726-9545219
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1098-5514
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pubmed:author |
pubmed-author:BrenchleyJason MJM,
pubmed-author:DouekDaniel CDC,
pubmed-author:GoldmanMitchellM,
pubmed-author:HageChadi ACA,
pubmed-author:KlattNichole RNR,
pubmed-author:KnoxKenneth SKS,
pubmed-author:KohliLisa MLM,
pubmed-author:TwiggHomer LHL3rd,
pubmed-author:VintonCarolC,
pubmed-author:WaltzJeffreyJ,
pubmed-author:ZwicklBethB
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pubmed:issnType |
Electronic
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9010-8
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pubmed:dateRevised |
2011-7-25
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pubmed:meshHeading |
pubmed-meshheading:20610726-Adult,
pubmed-meshheading:20610726-Anti-HIV Agents,
pubmed-meshheading:20610726-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:20610726-Blood,
pubmed-meshheading:20610726-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:20610726-CD4 Lymphocyte Count,
pubmed-meshheading:20610726-CD4-Positive T-Lymphocytes,
pubmed-meshheading:20610726-Female,
pubmed-meshheading:20610726-HIV Infections,
pubmed-meshheading:20610726-Humans,
pubmed-meshheading:20610726-Male,
pubmed-meshheading:20610726-Middle Aged,
pubmed-meshheading:20610726-Viral Load
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pubmed:year |
2010
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pubmed:articleTitle |
Reconstitution of CD4 T cells in bronchoalveolar lavage fluid after initiation of highly active antiretroviral therapy.
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pubmed:affiliation |
Southern Arizona VA Healthcare System and Arizona Respiratory Center and Division of Pulmonary and Critical Care Medicine, University of Arizona, Tucson, Arizona 85723, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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