Source:http://linkedlifedata.com/resource/pubmed/id/20610151
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
14
|
| pubmed:dateCreated |
2010-7-8
|
| pubmed:abstractText |
A novel family of 1H-imidazol-2-yl-pyrimidine-4,6-diamines has been identified with potent activity against the erythrocyte-stage of Plasmodium falciparum (Pf), the most common causative agent of malaria. A systematic SAR study resulted in the identification of compound 40 which exhibits good potency against both wild-type and drug resistant parasites and exhibits good in vivo pharmacokinetic properties.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
1464-3405
|
| pubmed:author |
pubmed-author:AdrianFranciscoF,
pubmed-author:ChangJonathanJ,
pubmed-author:ChatterjeeArnab KAK,
pubmed-author:ChenZhongZ,
pubmed-author:DengXianmingX,
pubmed-author:EkJaredJ,
pubmed-author:GrayNathanael SNS,
pubmed-author:HensonKerstinK,
pubmed-author:HowardStevenS,
pubmed-author:IsbellJohnJ,
pubmed-author:KuhenKelliK,
pubmed-author:NagleAdvaitA,
pubmed-author:PlouffeDavidD,
pubmed-author:SakataTomoyoT,
pubmed-author:SimersonSusanS,
pubmed-author:TullyDavid CDC,
pubmed-author:TuntlandToveT,
pubmed-author:WinzelerElizabethE,
pubmed-author:WuTaoT
|
| pubmed:copyrightInfo |
2010 Elsevier Ltd. All rights reserved.
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4027-31
|
| pubmed:meshHeading | |
| pubmed:year |
2010
|
| pubmed:articleTitle |
Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials.
|
| pubmed:affiliation |
Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 250 Longwood Ave., SGM 628, Boston, MA 02115, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|