Source:http://linkedlifedata.com/resource/pubmed/id/20609189
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2010-7-8
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| pubmed:abstractText |
The aim of this study was to investigate the relationship between serum apolipoprotein (apo) A-IV levels and markers for atherosclerosis, including carotid intima-media thickness (CIMT) and the ankle-brachial index (ABI), in hemodialysis patients. We performed a cross-sectional study involving 116 maintenance hemodialysis patients (70 males; median age, 64 years), measuring CIMT, ABI, the usual laboratory examinations, and serum apo A-IV before the dialysis session. The apo A-IV concentration was measured by a noncompetitive ELISA. Serum apo A-IV concentrations were significantly lower in hemodialysis patients with cardiovascular disease and plaque in the carotid artery. The apo A-IV level was positively associated with urea nitrogen and creatinine, and negatively associated with age, interleukin-6, the neutrophil/lymphocyte ratio, and maximum CIMT. Moreover, serum apo A-IV concentrations were significantly lower in the low ABI group. On logistic analysis, patients with high apo A-IV levels had a lower odds ratio for atherosclerosis (maximum CIMT > 1.0) and cardiovascular disease compared to patients with low apo A-IV levels. On stepwise multivariate regression analysis, the serum apo A-IV level was independently associated with creatinine, the neutrophil/lymphocyte ratio, and the maximum CIMT. Serum apo A-IV is associated with atherosclerotic lesions in hemodialysis patients. Apo A-IV levels may be useful for estimating the risk of cardiovascular disease in dialysis patients.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
1744-9987
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
14
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
341-8
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| pubmed:meshHeading |
pubmed-meshheading:20609189-Adult,
pubmed-meshheading:20609189-Aged,
pubmed-meshheading:20609189-Apolipoproteins A,
pubmed-meshheading:20609189-Atherosclerosis,
pubmed-meshheading:20609189-Biological Markers,
pubmed-meshheading:20609189-Cardiovascular Diseases,
pubmed-meshheading:20609189-Carotid Arteries,
pubmed-meshheading:20609189-Cross-Sectional Studies,
pubmed-meshheading:20609189-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:20609189-Female,
pubmed-meshheading:20609189-Humans,
pubmed-meshheading:20609189-Male,
pubmed-meshheading:20609189-Middle Aged,
pubmed-meshheading:20609189-Multivariate Analysis,
pubmed-meshheading:20609189-Regression Analysis,
pubmed-meshheading:20609189-Renal Dialysis,
pubmed-meshheading:20609189-Risk Factors,
pubmed-meshheading:20609189-Tunica Intima,
pubmed-meshheading:20609189-Tunica Media
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| pubmed:year |
2010
|
| pubmed:articleTitle |
Impact of serum apolipoprotein A-IV as a marker of cardiovascular disease in maintenance hemodialysis patients.
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| pubmed:affiliation |
Department of Nephrology, Gyoutoku Sougou Hospital, Chiba, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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