Source:http://linkedlifedata.com/resource/pubmed/id/20609172
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2010-10-15
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| pubmed:abstractText |
We examined serum IL-6 and IgE assays as adjuncts to VL monitoring for PTLD. Paediatric solid organ transplant recipients were followed with VL monitoring. VL, IL-6, and IgE assays were compared between PTLD cases and non-cases at <3, 3-6 and >6 months after transplantation. Median IL-6 levels in PTLD cases were 15.5 (2.0-87.1) and 23.3 (2.1-276) pg/mL compared with 3.25 (0.92-114) and 3.5 (0.75-199.25) pg/mL in non-cases at 3-6 and >6 months, respectively (p = 0.006 and p = 0.005). At >6 months, IL-6 levels correlated with VL and PTLD occurrence (Spearman's coefficients = 0.40; p = 0.001 and 0.32; p = 0.003) in univariate analyses. No benefit was derived from performance of IgE levels. The sensitivity and specificity of high VL as a test of PTLD were 76.3% and 92.5%, while the negative predictive value and PPV of VL were 94.9% and 68.4%, respectively. Combining elevated IL-6 with high VL increased the PPV and specificity to 80% and 96.2%, respectively, and improved the receiver operating characteristic curve. Serum IL-6 levels can improve the clinician's ability to identify PTLD, among patients with elevated EBV viral loads.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
1399-3046
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| pubmed:author |
pubmed-author:AllenU DUD,
pubmed-author:BartonMM,
pubmed-author:ChanMM,
pubmed-author:DipchandAA,
pubmed-author:EBV and Associated Viruses Collaborative Research Group,
pubmed-author:FecteauAA,
pubmed-author:GrantDD,
pubmed-author:HébertDD,
pubmed-author:ONGS TST,
pubmed-author:ReadSS,
pubmed-author:SolomonMM,
pubmed-author:StephensDD,
pubmed-author:TellierRR,
pubmed-author:WasfySS
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| pubmed:copyrightInfo |
© 2010 John Wiley & Sons A/S.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
14
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
852-8
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| pubmed:meshHeading |
pubmed-meshheading:20609172-Adolescent,
pubmed-meshheading:20609172-Area Under Curve,
pubmed-meshheading:20609172-Biological Markers,
pubmed-meshheading:20609172-Child,
pubmed-meshheading:20609172-Child, Preschool,
pubmed-meshheading:20609172-Cohort Studies,
pubmed-meshheading:20609172-Female,
pubmed-meshheading:20609172-Herpesvirus 4, Human,
pubmed-meshheading:20609172-Humans,
pubmed-meshheading:20609172-Immunoglobulin E,
pubmed-meshheading:20609172-Infant,
pubmed-meshheading:20609172-Interleukin-6,
pubmed-meshheading:20609172-Leukocytes, Mononuclear,
pubmed-meshheading:20609172-Lymphocytes,
pubmed-meshheading:20609172-Lymphoproliferative Disorders,
pubmed-meshheading:20609172-Male,
pubmed-meshheading:20609172-Prospective Studies,
pubmed-meshheading:20609172-Sensitivity and Specificity,
pubmed-meshheading:20609172-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:20609172-Viral Load
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| pubmed:year |
2010
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| pubmed:articleTitle |
Exploring beyond viral load testing for EBV lymphoproliferation: role of serum IL-6 and IgE assays as adjunctive tests.
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| pubmed:affiliation |
Division of Infectious Disease, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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