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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2010-11-10
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pubmed:abstractText |
Nucleotide depletion induced by the immunosuppressant mycophenolate mofetil (MMF) has been shown to exert neuroprotective effects. It remains unclear whether nucleotide depletion directly counteracts neuronal demise or whether it inhibits microglial or astrocytic activation, thereby resulting in indirect neuroprotection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1365-2990
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pubmed:author |
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pubmed:copyrightInfo |
© 2010 The Authors. Neuropathology and Applied Neurobiology © 2010 British Neuropathological Society.
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pubmed:issnType |
Electronic
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
598-611
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pubmed:meshHeading |
pubmed-meshheading:20609108-Animals,
pubmed-meshheading:20609108-Anti-Inflammatory Agents,
pubmed-meshheading:20609108-Apoptosis,
pubmed-meshheading:20609108-Astrocytes,
pubmed-meshheading:20609108-Cell Proliferation,
pubmed-meshheading:20609108-Coculture Techniques,
pubmed-meshheading:20609108-Guanosine,
pubmed-meshheading:20609108-Hippocampus,
pubmed-meshheading:20609108-Immunosuppressive Agents,
pubmed-meshheading:20609108-Inflammation,
pubmed-meshheading:20609108-Interleukin-1beta,
pubmed-meshheading:20609108-Microglia,
pubmed-meshheading:20609108-Microscopy, Confocal,
pubmed-meshheading:20609108-Mycophenolic Acid,
pubmed-meshheading:20609108-Neurons,
pubmed-meshheading:20609108-Neuroprotective Agents,
pubmed-meshheading:20609108-Nitric Oxide,
pubmed-meshheading:20609108-Rats,
pubmed-meshheading:20609108-Rats, Wistar,
pubmed-meshheading:20609108-Tumor Necrosis Factor-alpha
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pubmed:year |
2010
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pubmed:articleTitle |
Inhibition of microglial and astrocytic inflammatory responses by the immunosuppressant mycophenolate mofetil.
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pubmed:affiliation |
Dr. Senckenbergische Anatomie, Institute of Anatomy 2, Goethe-University, Frankfurt am Main, Germany. faramarz.dehghani@medizin.uni-leipzig.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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