| pubmed-article:2060845 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2060845 | lifeskim:mentions | umls-concept:C0038435 | lld:lifeskim |
| pubmed-article:2060845 | lifeskim:mentions | umls-concept:C1801960 | lld:lifeskim |
| pubmed-article:2060845 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:2060845 | lifeskim:mentions | umls-concept:C0022116 | lld:lifeskim |
| pubmed-article:2060845 | lifeskim:mentions | umls-concept:C0035126 | lld:lifeskim |
| pubmed-article:2060845 | lifeskim:mentions | umls-concept:C0085403 | lld:lifeskim |
| pubmed-article:2060845 | pubmed:dateCreated | 1991-8-7 | lld:pubmed |
| pubmed-article:2060845 | pubmed:abstractText | The objective of this study was to test the hypothesis that the extracellular oxidation of glutathione (GSH) may represent an important mechanism to limit hepatic ischemia/reperfusion injury in male Fischer rats in vivo. Basal plasma levels of glutathione disulfide (GSSG: 1.5 +/- 0.2 microM GSH-equivalents), glutathione (GSH: 6.2 +/- 0.4 microM) and alanine aminotransferase activities (ALT: 12 +/- 2 U/l) were significantly increased during the 1 h reperfusion period following 1 h of partial hepatic no-flow ischemia (GSSG: 19.7 +/- 2.2 microM; GSH 36.9 +/- 7.4 microM; ALT: 2260 +/- 355 U/l). Pretreatment with 1,3-bis-(2-chloroethyl)-1-nitrosourea (40 mg BCNU/kg), which inhibited glutathione reductase activity in the liver by 60%, did not affect any of these parameters. Biliary GSSG and GSH efflux rates were reduced and the GSSG-to-GSH ratio was not altered in controls and BCNU-treated rats at any time during ischemia and reperfusion. A 90% depletion of the hepatic glutathione content by phorone treatment (300 mg/kg) reduced the increase of plasma GSSG levels by 54%, totally suppressed the rise of plasma GSH concentrations and increased plasma ALT to 4290 +/- 755 U/l during reperfusion. The data suggest that hepatic glutathione serves to limit ischemia/reperfusion injury as a source of extracellular glutathione, not as a cofactor for the intracellular enzymatic detoxification of reactive oxygen species. | lld:pubmed |
| pubmed-article:2060845 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2060845 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2060845 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2060845 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2060845 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2060845 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2060845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2060845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2060845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2060845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2060845 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2060845 | pubmed:issn | 8755-0199 | lld:pubmed |
| pubmed-article:2060845 | pubmed:author | pubmed-author:JaeschkeHH | lld:pubmed |
| pubmed-article:2060845 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2060845 | pubmed:volume | 12-13 Pt 2 | lld:pubmed |
| pubmed-article:2060845 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2060845 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2060845 | pubmed:pagination | 737-43 | lld:pubmed |
| pubmed-article:2060845 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2060845 | pubmed:meshHeading | pubmed-meshheading:2060845-... | lld:pubmed |
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| pubmed-article:2060845 | pubmed:meshHeading | pubmed-meshheading:2060845-... | lld:pubmed |
| pubmed-article:2060845 | pubmed:meshHeading | pubmed-meshheading:2060845-... | lld:pubmed |
| pubmed-article:2060845 | pubmed:meshHeading | pubmed-meshheading:2060845-... | lld:pubmed |
| pubmed-article:2060845 | pubmed:meshHeading | pubmed-meshheading:2060845-... | lld:pubmed |
| pubmed-article:2060845 | pubmed:meshHeading | pubmed-meshheading:2060845-... | lld:pubmed |
| pubmed-article:2060845 | pubmed:meshHeading | pubmed-meshheading:2060845-... | lld:pubmed |
| pubmed-article:2060845 | pubmed:meshHeading | pubmed-meshheading:2060845-... | lld:pubmed |
| pubmed-article:2060845 | pubmed:meshHeading | pubmed-meshheading:2060845-... | lld:pubmed |
| pubmed-article:2060845 | pubmed:meshHeading | pubmed-meshheading:2060845-... | lld:pubmed |
| pubmed-article:2060845 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:2060845 | pubmed:articleTitle | Vascular oxidant stress and hepatic ischemia/reperfusion injury. | lld:pubmed |
| pubmed-article:2060845 | pubmed:affiliation | Center for Experimental Therapeutics, Baylor College of Medicine, Houston, Texas 77030. | lld:pubmed |
| pubmed-article:2060845 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2060845 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2060845 | lld:pubmed |
