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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-11-8
pubmed:abstractText
The family of two-pore domain potassium (K(?P)) channels is important in setting and controlling the background potassium current of excitable cells. This study examines the localisation of the acid-sensitive channel, K(?P)9.1 (TASK3), in cells of the gastric mucosa. We observed K(?P)9.1 immunoreactivity in endocrine cells of the mucosal glands of the guinea-pig, rat and mouse but the channels were not detected in parietal, chief, or mucous cells. K(?P)9.1 channel immunoreactivity was consistently co-localised with histidine decarboxylase immunopositive enterochromaffin-like (ECL) cells, and with the majority of ghrelin immunoreactive X/A cells. Localisation in somatostatin immunoreactive D cells was rare in the guinea-pig, and did not occur in the stomach of rat, but, in the mouse, K(?P)9.1 channels were observed in the majority of somatostatin-immunoreactive D cells. Conversely, sections taken from the guinea-pig and mouse stomachs, but not rat stomach, revealed K(?P)9.1 in gastrin-containing G cells. These results demonstrate the presence of K(?P)9.1 channels in the entero-endocrine ECL, G and D cell populations of the stomach that regulate acid secretion through the release of histamine, gastrin and somatostatin. K(?P)9.1 channels were located in the ghrelin X/A cells that regulate food intake.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1567-2387
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
403-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Identification of endocrine cells of the stomach that express acid-sensitive background potassium (K(2P)9.1/TASK3) channels.
pubmed:affiliation
Department of Anatomy & Cell Biology, University of Melbourne, Parkville, VIC 3010, Australia. k.needham@unimelb.edu.au
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't